___________________________________________________________________________________________ *Corresponding author: Email: chairmo2013@gmail.com; British Journal of Medicine & Medical Research 3(4): 1835-1846, 2013 SCIENCEDOMAIN international www.sciencedomain.org Enhancement of Intestinal Motility and Transit Time in Streptozotozin-Induced Diabetic Rats Treated with Ocimum gratissimum Okon Uduak Akpan 1* , Obembe Agona Odeh 2 , Ita Sunday Otu 1 and Osim Eme.E 2 1 Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Uyo, Uyo, Akwa Ibom State, Nigeria. 2 Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria. Authors’ contributions This work was carried out in collaboration between all authors. Author OUA designed the study, coordinated the research, and wrote the first draft of the manuscript. Author OAO managed the analysis and interpretation of data. Author ISO wrote the protocol and managed the literature searches. Author OEE supervised and guided the entire experimental procedure. All authors read and approved the final manuscript. Received 30 th March 2013 Accepted 30 th May 2013 Published 16 th June 2013 ABSTRACT Aims: Acute changes in the blood glucose concentration have a substantial effect on intestinal motility in both diabetic and healthy subjects. This research work was therefore designed to assess the effect of DM on GIT motor activity and the impact of treatment with OG on same. Methodology: The phytoconstituents and median lethal dose of the plant extract was determined before administration. Eighteen rats were used; the animals were divided into three groups of six rats each. Group 1 served as the control which was fed with normal feed. Group 2 was diabetic untreated rats (DM) while group 3 was OG treated diabetic rats (DMT). At the end of 28 days, the intestinal transit and motility were determined using graded doses of acetylcholine, adrenaline and atropine. Results: The DMT intestine showed greater increase in contraction with increase in concentration of acetylcholine, application of adrenaline showed that the ileum of the DMT had a significantly lower (P=.001) percentage change in relaxation when compared Research Article