THE EFFECT OF CHROME-COBALT AND ACRYLIC PALATAL PLATES ON EXPERIMENTAL DENTURE STO- MATITIS IN WISTAR RAT Muhannad Ali Kashmoola 1 , Basma Ezzat Mustafa 2 , Nazih Shaaban Mustafa 3 , 1 Depart- ment of Oral Pathology and Medicine, Kulliyyah of Dentistry, International Islamic University Malaysia; 2 Department of Basic Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia; 3 Department of Oral and Maxillofacial Surgery, Kulliyyah of Dentistry, International Islamic University Malaysia Objective: To compare effect of acrylic and chrome-cobalt on experimental oral candidiasis. Study Design: 72 male Wistar rats were divided into group1 and group2 experimental groups and a control group, group 1 includes animals fitted with acrylic palatal plates, 12 of them inoculated with candida albicans, group 2 includes animals fitted with chrome-cobalt palatal plates, 12 of them inoculated with candida albicans. The control group includes animals inoc- ulated with candida albicans on palate, and animals left without any treatment. Results: Palatal candidiasis resulted in group 1, with alternating epithelial hyperplasia and atrophy, intra-epithelial polymorphonuclear leukocyte infiltration and chronic inflam- matory cell infiltration in connective tissue, transmission of candida from yeast into mycelium was observed. Group 2 did not exhibit palatal candidiasis; but only slight hyperorthokeratinization. Conclusions: Presence of acrylic in association with Candida albicans is required for oral candidiasis, while Chrome- Cobalt Inoculated with Candida albicans caused hyperkeratosis and slight epithelial hyperplasia. Keywords: experimental, oral candidiasis, candida albi- cans, chrome-cobalt, acrylic, rat, IMMUNOLOGICAL CHANGES IN SECONDARY SJOG- RAN SYNDROME (COMPARATIVE STUDY) Basma Ezzat Mustafa Alahmad 1 , Nazih Sh. Mustafa 2 , Muhannad A. Kashmoola 3 , Raida Khalil 4 , 1 Assistant Professor, Head of Dept. of Basic Medical Sciences, Kulliyyah of Dentistry, In- ternational Islamic University Malaysia; 2 Assistant Professor, Head of Dept. of Oral and Maxillofacial Surgery, Kulliyyah of Dentistry, International Islamic University Malaysia; 3 Asso- ciate Professor, Dean, Head of Dept. of Oral Pathology and Oral Medicine, Kulliyyah of Dentistry, International Islamic University Malaysia; 4 Associate Professor, Department of Biotechnology and Genetic Engineering, Philadelphia Uni- versity, Jordan Objective: This study was designed to evaluate the immu- nological changes and its existence for early diagnosis and proper management of disease. Study Design: 56 patients with RA accompanied by sSS where included in this study and compared to 60 RA patients without sSS.Schirmers test, blood tests and search for auto anti- bodies was done for all patients in both groups. Schirmers, blood tests and search for antinuclear antibody was done for all patients in both groups, with the measurement of salivary flow rate. Results: Schirmers test was positive in all sSS and negative in all RA patients, whilst salivary flow rate was reduced in all sSS. Latex fixation test, ANA, Anti Ro and Anti La were reported significantly higher in sSS (p<0.01) Conclusions: Secondary Sjogrens syndrome had a signifi- cantly positive rheumatoid factor, antinuclear antibody, anti Ro (SS-A) and anti La (SS-B) compared to rheumatoid patients without Sjogrens syndrome. Keywords: Immunological Changes,Secondary Sjogran Syndrome THE EFFECT OF NOVEL FLAX OIL-BASED IMPLANT COATING ON BONE HEALING PROCESS (IN VIVO ANIMAL STUDY) Nazih Shaaban Mustafa 1 , Basma E. Mustafa Al Ahmad 2 , Ammar A. Mustafa 3 , Muhannad A. Kashmoola 4 , 1 Assistant Professor, Head of Dept. of Oral and Maxillofacial Surgery, Kulliyyah of Dentistry, International Islamic University Malaysia; 2 Assistant Professor, Head of Dept. of Basic Medical Sciences, Kulliyyah of Dentistry, In- ternational Islamic University Malaysia; 3 Assistant Professor, Kulliyyah of Dentistry, International Islamic University Malaysia; 4 Associate Professor, Dean, Head of Dept. of Oral Pathology and Oral Medicine, Kulliyyah of Dentistry, Inter- national Islamic University Malaysia Objective: This pilot study was designed to investigate the effect of new implant coating material on postoperative bone healing process. Study Design: experimental formula of flax oil-based implant coating was prepared.Twelve (12) white New Zealand male rabbits were randomly distributed into four groups (n¼3). Surgery was performed to prepare 2mm hole in the zygomatic bone. The right side was filled with the test material (test group). whereas the hole in the left side of the same animal was left material free. Bone healing process was investigated after 3,7,14, and 21 days. Results: New growth of normal bone explained by active bone apposition was observed in the test operation area in the marrow space after three days, less postoperative inflammation was observed explained by less inflammatory cells in the opera- tion area. Conclusıons: The new formula could represent a promising implant coating material for better bone healing process and hence faster osseointegration. Keywords: Flax seed, coating, implant, Bone, Rabbit CASTLEMAN DISEASE: A DIAGNOSTIC DILEMMA Rabia Bozdogan Arpaci 1 , Cetin Kocak 3 , Yasemin Yuyucu Karabulut 1 , Ebru Serinsoz Linke 1 , Tuba Kara 1 , Cengiz Ozcan 2 , 1 Department of Pathology, Mersin University, Mer- sin, Turkey; 2 Department of Otorhinolaryngology, Mersin University, Mersin, Turkey; 3 Odak Pathology, Mersin Castleman Disease (CD) is a benign lymphoproliferative disease. The etiology is still unknown. It was first described by Castleman et al. in 1956. Clinically it is rare and is always a diagnostic dilemma. It mostly seems in adults and it is rare in children. Mediastinum is the most common location and followed by neck, abdomen and axilla. It might be also found in lymph nodes in any region of the body. There are two pathological subtypes such as hyalen vascular type (%90) and plasma cell type (%10). In the parotid re- gion it is also rare and very difficult to reach the correct diagnosis particularly with fine needle aspiration (FNA) and also by histologically. Here we present a rare case of CD in parotid gland region findings of FNA and histological features. ORAL AND MAXILLOFACIAL PATHOLOGY OOOO e126 Abstracts March 2015