_____________________________________________________________________________________________________ *Corresponding author: E-mail: Inform.shambhu@gmail.com; J. Appl. Life Sci. Int., vol. 26, no. 5, pp. 58-65, 2023 Journal of Applied Life Sciences International Volume 26, Issue 5, Page 58-65, 2023; Article no.JALSI.104979 ISSN: 2394-1103 Serialized Barcode Printing Solution for Drug Traceability: An Architectural Design and Approach Shambhu Sarkar a* a Micro-master in Healthcare Administration, USA. Author’s contribution The sole author designed, analysed, interpreted and prepared the manuscript. Article Information DOI: 10.9734/JALSI/2023/v26i5619 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/104979 Received: 11/07/2023 Accepted: 16/09/2023 Published: 22/09/2023 ABSTRACT Medicine serialization seems to be a key to both counterfeiting and the complex supply chain of the pharmaceutical industry, including recalls and returns. Though there are countries that use serialization as a legal necessity, it is still a developing topic within the industry. Serialization is not just for anti-counterfeit technology but also to use supply chain and stock management more proficiently. The design of the Barcode is a fundamental requirement as per Healthcare Distribution Alliance (HDA) guidelines for serialized products. Encoding Barcodes on pharmaceutical drugs with critical product attributes is necessary for tracking and validating product sources. Since the serialization guidelines are regulated, small-scale pharmaceutical companies are struggling to comply with regulations due to heavy investments. Printing Serialized labels with barcodes required specialized third-party systems and software. The cost of third-party systems that integrate with ERP and Serialized systems for exchanging data is very expensive. On the other hand, the operational and sustainability costs of these systems will be an additional year-to-year cost for the company. Aim: This Study investigated the feasibility of designing a barcode printing solution for drug traceability. Original Research Article