Vol:.(1234567890) Digestive Diseases and Sciences (2019) 64:232–240 https://doi.org/10.1007/s10620-018-5304-0 1 3 ORIGINAL ARTICLE Diferences in Prevalence of Large Polyps Between Hispanic Americans from Mexican‑ and Non‑Mexican‑Predominant States Danny J. Avalos 1  · Marc J. Zuckerman 1  · Alok Dwivedi 2  · Christopher Dodoo 2  · Jinendra Satiya 3  · Fernando J. Castro 4 Received: 21 June 2018 / Accepted: 24 September 2018 / Published online: 1 October 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract Background There have been conficting reports comparing the prevalence of large polyps (>9 mm) between Hispanics and non-Hispanic whites (NHW). Diferences between Hispanic subpopulations may account for these variations. Aims We aimed to assess the prevalence of large polyps (>9 mm) in Hispanics from Mexican- and non-Mexican-predominant states compared with NHW. As secondary outcome, we evaluated results by polyp location. Methods The 2010 U.S. Census Bureau was used to identify states with a predominantly Mexican Hispanic (West) versus non-Mexican Hispanic (East) populations. Average-risk colonoscopies in those states from 2001 to 2014 were accessed using the Clinical Outcomes Research Initiative database. Military and Veteran’s Administration sites were excluded. Hispanics were compared with NHW in each geographical location using hierarchical logistic regression analysis. Results A total of 65,138 procedures were included with 33,425 procedures in the West (14.5% Hispanics) and 31,713 pro- cedures in the East (44.0% Hispanics,). East Hispanics had signifcantly less odds of large polyps, OR 0.74, CI 0.58–0.94, p = 0.02, while West Hispanics exhibited no diference, OR 0.91, CI 0.76–1.10, p = 0.33, compared with NHW. Eastern Hispanics had less odds of large distal polyps, OR 0.69, CI 0.52–0.91, p = 0.01, and no diference in proximal polyps com- pared with NHW. Among Western Hispanics, no diferences were seen in proximal, OR 1.06, CI 0.83–1.35, p = 0.66, or distal polyps, OR 0.83, CI 0.68–1.02, p = 0.08, compared with NHW. Conclusion Using NHW as a reference, Hispanics from Mexican-predominant states have a similar prevalence of large pol- yps, while Hispanics from non-Mexican-predominant states have a lower prevalence. Diferences in Hispanic subpopulations likely explain previous conficting reports on the prevalence of large polyps in Hispanics and NHW. Keywords Hispanic Americans · Polyps · Colonoscopy · Prevalence * Fernando J. Castro Castrof@ccf.org Danny J. Avalos Danny.avalos@ttuhsc.edu Marc J. Zuckerman Marc.Zuckerman@ttuhsc.edu Alok Dwivedi Alok.dwivedi@ttuhsc.edu Christopher Dodoo Christopher.dodoo@ttuhsc.edu Jinendra Satiya Jinen19@gmail.com 1 Division of Gastroenterology, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA 2 Biostatistics and Epidemiology Consulting Lab, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA 3 University of Miami/JFK GME Consortium, Atlantis, FL, USA 4 Digestive Disease Center, Department of Gastroenterology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL 33331, USA