Research Article Metabolic Abnormalities in a Cohort of Overweight and Obese Children in an Urban Setting of Sri Lanka Loretta S. Warnakulasuriya, 1 Dulani L. Samaranayake, 2 Adikaram V. N. Adikaram, 3 Manel M. A. Fernando, 4 Elisabet Rytter, 5 Iris Ciba, 6,7 Peter Bergsten, 6,7,8 Anders H. Forslund, 6,7 K. D. Renuka Ruchira Silva, 9 and Vithanage Pujitha Wickramasinghe 10 1 Postgraduate Institute of Medicine, University of Colombo, Colombo, Sri Lanka 2 Department of Community Medicine, University of Colombo, Colombo, Sri Lanka 3 Health Unit, Bandaranaike International Airport, Katunayake, Sri Lanka 4 Colombo North Teaching Hospital, Ragama, Sri Lanka 5 Clinical Nutrition and Metabolism, Department of Public Health and Caring Science, Faculty of Medicine, Uppsala University, Uppsala, Sweden 6 Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden 7 Uppsala University Children’s Hospital, Uppsala, Sweden 8 Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden 9 Department of Applied Nutrition, Wayamba University of Sri Lanka, Makandura, Gonawila, Sri Lanka 10 Department of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka Correspondence should be addressed to Vithanage Pujitha Wickramasinghe; pujitha@pdt.cmb.ac.lk Received 14 March 2021; Revised 24 May 2021; Accepted 21 June 2021; Published 5 July 2021 Academic Editor: GianLuca Colussi Copyright © 2021 Loretta S. Warnakulasuriya et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Childhood obesity-related metabolic derangements are increasing among South Asian populations. Most of these changes persist to adulthood. is study aims to describe the distribution of metabolic abnormalities among 7- to 17-year-old overweight and obese children in the Gampaha District of Sri Lanka. Overweight children (age- and gender-adapted BMI>+1SD, WHO standards) were selected from a community survey carried out in the Negombo Education Zone of Gampaha District. After a 12- hour overnight fast, blood was drawn, and blood glucose (FBG), lipid profile, insulin, and liver transaminases were measured. Two hours after a glucose load, blood was drawn for random blood glucose (RBG) and insulin. Metabolic syndrome (MetS) was diagnosed using modified IDF criteria for children. Anthropometry, fat mass (FM), and blood pressure were measured. Hepatic fat pattern was assessed ultrasonically. e data of 403 children (210 boys) were analysed. Of the study population, 16.4% were overweight (BMI for age +1 to +2SD), 72% were obese (BMI for age >+2 to +3SD), and 11.6% were severely obese (BMI for age >+3SD). Insulin resistance was seen in 46.8%, and prevalence increased with age. Mean postprandial insulin ranged from 368 to 625 pmol/L and was elevated in 35%. Dysglycaemia was seen among 20.8%. MetS was present in 19.8%, and 84% had at least one metabolic abnormality. Different degrees of hepatic steatosis were observed in 32.5%, and elevated ALT/ASTratio was seen in 58% of the population. Overweight and obesity during childhood were associated with multiple metabolic abnormalities including MetS, and they occur from a young age. It is important to screen children for overweight/obesity early in life and intervene to prevent them from developing metabolic complications. Hindawi International Journal of Endocrinology Volume 2021, Article ID 9936889, 10 pages https://doi.org/10.1155/2021/9936889