Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial $ Farrukh Aslam Khalid * , Muhammad Younas Mehrose, Muhammad Saleem, Muhammad Amin Yousaf, Abdul Malik Mujahid, Saif Ur Rehman, Sania Ahmad, Moazzam Nazeer Tarar Jinnah Burn and Reconstructive Surgery Center, Allama Iqbal Medical College, Lahore, Pakistan a b s t r a c t The treatment of keloid and hypertrophic scar is challenging with no universally accepted mode for permanent ablation. Conventional therapies yield unpredictable results, signifi- cant complications and require elaborate hardware. Objective: The objective was to establish the safety and efficacy of intralesional 5-fluorouracil (5-FU) for the treatment of keloids and hypertrophic scars. Study design: Randomized controlled trial (RCT). Place and duration: It was conducted at the Jinnah Burn and Reconstructive Surgery Center/ Allama Iqbal Medical College, Lahore, Pakistan from May 2012 to March 2013. Subjects and methods: We included 120 patients divided in two groups. The group A patients received intralesional triamcinolone acetonide (TAC) and the group B patients received both 5-FU and TAC. 8 injections at a week interval were given and patients were evaluated at the start of treatment and then at 4th and at 8th week during the treatment and then 4 weeks after the end of treatment. Patents were assessed for mean reduction in scar height, efficacy and complications. Results: Total of 108 patients completed the study. The mean reduction in the scar height in group B (5-FU+TAC) 1.144+.4717 was markedly better than that of group A (TAC alone) 1.894 + 1.0751 (t=4.781, p=.000). The efficacy (defined previously as >50% reduction in initial scar height) was superior in group B 44 (77.2%) than that of group A 25 (49.0% (X2=9.260, p=.002). Recurrence was seen in 39.2% (20) of patients of the group A while in only 17.5% (10) of the cases of group B (P=0.012). Mean follow up was of 22 months. Conclusion: 5-FU+TAC is safe, easy to administer and effective treatment for problematic scars and has the lower rate of recurrence on larger follow up. © 2018 Elsevier Ltd and ISBI. All rights reserved. a r t i c l e i n f o Article history: Accepted 7 August 2018 Available online xxx Keywords: Keloid Hypertrophic scar 5-Fluorouracil Double blind Randomized control trial $ Poster presentation at the International Society of Burn Injuries, August, 2016 at Miami, Florida, USA. * Corresponding author. E-mail address: drfarrukhaslam@gmail.com (F.A. Khalid). https://doi.org/10.1016/j.burns.2018.08.011 0305-4179/© 2018 Elsevier Ltd and ISBI. All rights reserved. b u r n s x x x ( 2 0 1 8 ) x x x – x x x JBUR 5615 No. of Pages 7 Please cite this article in press as: F.A. Khalid, et al., Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial, Burns (2018), https://doi.org/10.1016/j.burns.2018.08.011 Available online at www.sciencedirect.com ScienceDirect jo u rn al h o mep age: w ww .elsevier .co m /loc ate/b u rn s