refugees. Common barriers to research participation that we expect are mistrust, financial constraints, fear of unintended out- comes, stigma about participating in research, and fear of depor- tation or concern of immigration status. We plan to address these barriers by hiring bilingual Somali recruiter/interviewer, translat- ing study materials, reassuring confidentiality of participant’s information, providing a $50 incentive, and implementing com- munity advisory board’s input on study design and recruitment sites. DISCUSSION/SIGNIFICANCE: Translational Impact: Findings from interviews will be disseminated and evaluated by members of the community and providers. Recommendations based on our findings can be applied in mental healthcare prac- tice to reduce identified barriers. Community dissemination can also promote the destigmatization of mental healthcare in the Somali community. 244 “I am interested!”: Lessons Learned from the All IN for Health/Indiana CTSI Health Advisory Board Sylk Sotto-Santiago, Sarah Wiehe, Gina Claxton, Lindsey Delp, Brenda Hudson, Sharon Moe Indiana CTSI OBJECTIVES/GOALS: All IN for Health’s Advisory Board is an active board providing advice on strategic directions, feedback, con- tributing ideas, and accountability. Most recently, the HAB had 4 openings. A call to our community of over 13,000 individuals was published. We received 488 applications. We share the lessons in motivations and interests shared respondents. METHODS/ STUDY POPULATION: Four hundred eighty-eight individuals sub- mitted applications for participation in the All IN for Health Advisory Board. The call went out to the All IN for Health volunteer research network comprised of community members across the state.The call mentioned a nominal compensation of $50/hour, and time commitment of a 2-hour board meetings via video confer- encing every 3 months. The application process included the follow- ing questions: 1. What lived experiences and/or personal interests have motivated you to be involved in All IN for Health? 2. Please explain why you are interested in being an All IN for Health Advisory Board member? RESULTS/ANTICIPATED RESULTS: We organize the findings in two categories: Motivation and Interests. The motivation category refers to individual’s motivation to be part of the All IN for Health initiative. Interest category referred to individual’s specific interest in participating in the All IN for Health Advisory Board. Individuals were motivated to participate based on (1) family or friend diagnosis, (2) personal diagnosis, (3) roles as caregivers, (4) desire to impact change and advocacy, (5) role as health professional, and (6) previous participation in research. Interests followed similar themes with additional categories of shar- ing their experience, previous research and board experience, as well as a desire to educate future generations of researchers. DISCUSSION/SIGNIFICANCE: We share the narratives honoring individual stories for the top three motivations and interest. This information can be used for recruitment to boards, research partici- pation, and healthcare advocacy, and highlights importance of shar- ing successes and challenges to the processes of forming and sustaining effective boards. 245 Do they REALLY Trust Us?: The Importance of Trust and Trustworthiness in All IN for Health Sylk Sotto-Santiago, Brenda Hudson, Gina Claxton, Lynsey Delp, Dustin Lynch, Sarah Wiehe, Sharon Moe Indiana Clinical and Translational Science Institute OBJECTIVES/GOALS: The critical role that trust plays continues to be documented and highlights the gap in understanding the extent to which initiatives such as All IN for Health from the Indiana Clinical and Translational Institute (I-CTSI) can improve trust between the community and researchers. We discuss mea- sures of trust and evaluate how we may improve recruitment. METHODS/STUDY POPULATION: In this study, we invited over 13000 volunteers from the All IN for Health research partici- pant registry. Six hundred and sixty-three (663) respondents par- ticipated in the survey. The Relationship of Trust and Research Engagement Survey included three validated surveys: Distrust in Healthcare Organizations, the Trust in Medical Researchers scale by Hall et. al, and Patient Trust in Medical Researchers by Mainous et al.. The 36-item survey also included open-text questions. RESULTS/ANTICIPATED RESULTS: Based on pre- liminary results 74% agreed it’s safe to be in medical research, yet 79% had never been asked to participate in medical research by their doctor. Sixty percent believed that HCOs put money above patients’ needs. Forty percent agreed that doctors do medi- cal research for selfish reasons. Fifty percent disagree that patients get the same medical treatment regardless of race/ethnicity. Moreover, 28 % agree that medical researchers act differently toward minorities. Between 9 and 11% believe that researchers select minorities for their most dangerous studies and some pro- jects are secretly designed to expose minoritized groups to dis- eases. Our next step is to disaggregate the data by race and ethnicity and evaluate these answers. DISCUSSION/ SIGNIFICANCE: This study's population willingly engaged in a research registry making their diminished trust quite alarming. Amongst the general population, trust in scientists is now below pre-pandemic levels. We must critically assess our own trustwor- thiness, and critically reflect on the authenticity of our efforts. 246 Motivators and Barriers to COVID-19 vaccination among Native American and Latino Communities Linda Ko 1 , Lina Truong 1 , Alexandra Adams 2 , Sonia Bishop 3 , Virgil Dupuis 4 , Lorenzo Garza 5 , Thomas Quigley 6 , Charlie Gregor 7 , and Eliza Webber 2 1 University of Washington 2 Montana State University, Center for American Indian and Rural Health Equity, Bozeman, MT 3 University of Washington, Department of Global Health, Seattle, WA 4 Salish Kootenai College, Extension Office, Pablo, MT 5 Sunnyside School District, Family and Community Engagement, Sunnyside, WA 6 Fred Hutchinson Cancer Research Center, Collaborative Data Services, Seattle, WA 7 University of Washington, Institute of Translational Health Sciences, Seattle, WA OBJECTIVES/GOALS: COVID-19 disproportionately impacts rural communities of color. Socioeconomic status, occupation and chronic JCTS 2023 Abstract Supplement 75 https://doi.org/10.1017/cts.2023.313 Published online by Cambridge University Press