woman with pyrexia of unknown origin and a 75-
year-old man with cardiac tamponade, in whom LE
cells were detected in bone marrow aspiration and
pericardial fluid samples, respectively; these cases
emphasize the importance of a meticulous morpho-
logical examination of smears irrespective of gender
and age of the patient, even in unusual situa-
tions.
7,8
To conclude, although well documented, LE cells
in pericardial effusions are extremely rare. Both cli-
nicians and cytopathologists should have a high
index of suspicion for SLE in any young woman pre-
senting with an unexplained serous effusion. When
numerous, LE cells are easily detectable in body
fluid samples, which is of paramount importance in
the early management of patients with SLE. Hence,
LE cell detection in body fluids is not merely of his-
torical interest, but has an enormous clinical signifi-
cance.
S. Rao, N. Siddaraju, P. Mishra, E. Muthalagan,
P. C. Toi and N. G. Rajesh
Department of Pathology, Jawaharlal Institute of
Postgraduate Medical Education and Research (JIPMER),
Pondicherry, India
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Fine needle aspiration cytology of inflammatory
pseudotumour of the spleen
DOI:10.1111/cyt.12147
Dear Editor, Splenic tumours are relatively rare and
difficult to diagnose before surgery. Inflammatory
pseudotumour (IPT) is a rare space-occupying lesion
of unknown aetiology, characterized by fibroblastic
proliferation with varying degrees of inflammatory
cell infiltration.
1
Fine needle aspiration cytology
(FNAC) is a safe and cost-effective technique for
making a definite pathological diagnosis of splenic
lesions.
2
In our department, splenic FNAC is not
usual, but, in the few cases that require pre-opera-
tive diagnosis, we perform it under ultrasound guid-
ance. In this report, we describe the FNAC findings
of splenic IPT.
A 40-year-old woman presented with constant left
upper quadrant abdominal pain. She had no history
of fever or significant weight loss. Physical examina-
tion revealed splenomegaly. Blood count results and
biochemical analysis were normal. Magnetic reso-
nance imaging revealed a 60 9 50-mm
2
, homo-
geneous, well-defined, round mass in the spleen.
The radiologist made a diagnosis of lymphoma.
Ultrasound-guided FNAC was performed using a
22-gauge needle and smears were stained with Papa-
nicolaou and Wright–Giemsa methods. FNAC of the
mass showed hypercellular smears composed of iso-
lated clusters of spindle cells admixed with some
lymphocytes, plasma cells, eosinophils and red blood
cells. The spindle cells appeared bland with no aty-
pia (Figure 1a,b). The possibility of a benign spindle
cell tumour was proposed. The patient underwent
splenectomy. Cut section of the spleen showed
a well-defined, white, firm mass measuring
6 9 5 9 5 cm
3
with areas of necrosis (Figure 2a).
Microscopically, the mass showed sheets of spindle
cells admixed with many inflammatory cells,
including lymphocytes, neutrophils, plasma cells,
eosinophils and histiocytes (Figure 2b). The spindle
Correspondence:
M. H. Anbardar, Department of Pathology, Shiraz
Medical School, Shiraz University of Medical
Sciences, PO Box 71345-1864, Shiraz, Iran
Tel./Fax: +98-711-2301784;
E-mail: anbardarm@sums.ac.ir
© 2014 John Wiley & Sons Ltd
Cytopathology 2015, 26, 197–204
Correspondence 202