Medical Sains : Jurnal Ilmiah Kefarmasian Vol. 8 No. 3, July – September 2023 https:/ojs.stfmuhammadiyahcirebon.ac.id/index.php/iojs 1165 Open Journal Systems STF Muhammadiyah Cirebon : ojs.stfmuhammadiyahcirebon.ac.id EFEK ANTI-INFLAMASI EMULGEL MINYAK BIJI PALA (Myristica fragrans) PADA MENCIT ANTI-INFLAMMATORY EFFECT OF NUTMEG OIL (Myristica fragrans) EMULGEL IN MICE MODEL Zulkaida 1* , Rizky Dwi Larasati 1 , Aliyah Alfita 1 , Hanif Nurqolbi 1 , Titian Daru Asmara Tugon 1 , Fauzia Ningrum Syaputri 1 1 Program Studi Farmasi, Fakultas Sains dan Teknologi, Universitas Muhammadiyah Bandung Jl. Soekarno Hatta No.752, Cipadung Kidul, Kec. Panyileukan, Kota Bandung, Jawa Barat 40614 *Email Corresponding: zulkaidafarmasi@umbandung.ac.id Submitted: 15 February 2023 Revised: 22 August 2023 Accepted: 11 September 2023 ABSTRAK Studi inflamasi pada kulit dengan pemberian minyak biji pala (Myristica fragrans) menjadi salah satu inovasi yang terus dikembangkan hingga saat ini. Penelitian sebelumnya menunjukkan bahwa formulasi elmulgel minyak biji pala memiliki potensi inhibitor peradangan berdasarkan komponen senyawa dan stabil secara fisik. Tujuan penelitian untuk mengetahui efek antiinflamasi elmulgel minyak biji pala pada model hewan uji mencit dengan induksi karagen 3%. Emulgel uji sediaan EMBP 3% (Emulgel minyak biji pala 3%), EMBP (Emulgel minyak biji pala 4,5%), EMBP (Emulgel minyak biji pala 6%). Metode yang digunakan inflammation associated edema untuk mengukur tebal lipatan kulit punggung hewan uji. Untuk mendapatkan perubahan lipatan punggung yang diinduksi dengan agen berdasarkan interval waktu. Hasil menunjukkan bahwa pemberian secara topical emulgel minyak biji pala memiliki aktivitas sebagai anti inflamasi. Formula berpotensi sebagai antiinflamasi tertinggi yaitu EMBP 3%. Kata kunci : Biji Pala, Anti-inflamasi, Minyak atsiri, Emulgel. ABSTRACT The study of inflammatory treatment of damaged skin tissue with nutmeg oil (Myristica fragrans) is one of the ever-growing innovations. Previous studies have shown that the nutmeg oil elmulgel formulation has the potential for pain inhibitors based on compound components and is physically stable. The aim of this study was to determine the anti- inflammatory effect of nutmeg oil elmulgels on the test animal model of mice with 3% carrageenen induction. Emulgel is available with EMBP 3% (Nutmeg oil emulgel 3%), EMBP 4.5% (Nutmeg oil emulgel 4.5%), EMBP 6% (Nutmeg oil emulgel 6%). The determination of the antiinflammatory effect is done with an associated oedema inflammation, i.e., by utilizing the use of porosity to measure the thickness of the skin folds of the back of the test animal. To obtain the change in the induced dorsal fold with the agent by time interval. In can be concluded that topically administering nutmeg oil emulgel has anti- inflammatory activity. Formulas have the potential to be the highest consecutive antiinflammatory agents: EMBP 3%. Keywords: Nutmeg, anti-inflammatory, essential oil, emulgel.