S160 Abstracts / Toxicology Letters 238S (2015) S56–S383 P05-063 What kind of adverse effects occurs in companion animals after chemotherapeutics drugs administration in two veterinary practices in Portugal? E.S.G. Cunha 1,* , B. São Braz 1,* , T. Nunes 2 , H. Vilhena 3 1 Faculdade de Medicina Veterinária, Farmacologia e Toxicologia, Lisboa, Portugal 2 Faculdade de Medicina Veterinária, Lisboa, Portugal 3 Hospital Veterinário do Baixo Vouga/Escola Universitária Vasco da Gama/CECAV, Coimbra, Portugal Introduction: Chemotherapeutic drugs (CDs) act mainly in cells with high mitotic rate, like neoplastic cells, but also in normal cells with high mitotic index, leading to adverse effects that are described in the literature. The purposes of this study were the characterization of adverse effects, exhibited by dogs and cats, after the administration of CDs and the evaluation of the efficacy of the control measures used in these situations. Material and methods: Dogs and cats presented to two veterinary medical centers in Portugal between 2008 and 2014 with malig- nant tumors and that were submitted to at least one chemotherapy session were included in the study. Animals were selected indepen- dently of gender, type of neoplasia or CDs administered. Adverse effects under analysis were identified through the clinical signs and laboratorial data and were related with the previous administration of a chemotherapeutic drug. Results: Forty-two animals were included in the study (36 dogs and 6 cats), who were submitted (in total) to 266 chemotherapeutic sessions. CDs administered include carbo- platin, cyclophosphamide, chlorambucil, doxorubicin, epirubicin, lomustine, masitinib, mitoxantrone, vinblastine, vincristine, QM (metronomic chemotherapy with cyclophosphamide and meloxi- cam), and QM and masitinib association. 57% of the animals (n = 24/42) had at least one episode of toxicity. Gastrointestinal (GI) (45.24%, n = 19/42) and hematologic (HE) toxicity (33.3%, n = 14/42) shows a clear predomination with severity toxicity grade of 1 and 2 which is mild to moderate (VCOG-CTCAE). Dermatologic toxic- ity, anaphylactic/allergic reactions, sterile hemorrhagic cystitis and cardiac toxicity were also identified. The specific control measures applied (delay chemotherapy, dose reduction and hospitalization with intensive monitoring of the severe cases) were effective to control adverse reactions. According to the results, the toxicity of chemotherapeutic drugs is common in pets, for that reason the vet- erinarian should be aware of their frequency and the best way to act in these situations also given information to the owners. http://dx.doi.org/10.1016/j.toxlet.2015.08.495 P05-064 MDPV intoxications over a five-year period: Results from the Swedish STRIDA project L. Franzén 1,* , M. Bäckberg 1 , O. Beck 2 , A. Helander 2 1 Swedish Poisons Information Centre, Stockholm, Sweden 2 Karolinska Institute and Karolinska University Laboratory, Department of Laboratory Medicine, Stockholm, Sweden Objective: Since its introduction on the new psychoactive substance (NPS) market, the cathinone derivative methylene- dioxypyrovalerone (MDPV) has generated a high number of calls to the Swedish Poisons Information Centre, despite being classified as a narcotic substance already in February 2010. Since January 2010, the STRIDA project has monitored trends in analytically confirmed acute poisonings involving NPS presenting at emergency depart- ments all over Sweden and collected data on associated clinical effects and harms. This study summarizes the results of analyti- cally confirmed MDPV intoxications in the STRIDA project over a 5-year period. Methods: Hospitalized patients from Sweden with suspected NPS intoxication were recruited to the STRIDA project. Blood and urine samples were analyzed by a multi-component LC–MS/MS method. The clinical results were processed retrospectively to establish the severity score of each poisoning (PSS), based on symp- toms documented in medical records. Results: From January 2010 to December 2014, 201 patients in the STRIDA project tested positive for MDPV. The age range of patients was 18–68 (mean 36) years and 70% were men. Two-thirds of the patients were hepatitis C positive and/or had an established drug abuse. In 30 cases (15%), MDPV was the only drug detected. Additional substances, including classical drugs of abuse, other NPS and/or ethanol, were detected in 171 (85%) of the 201 cases. The main clinical features reported in the single-substance intoxica- tions were tachycardia (≥100/min), agitation, and hypertension (systolic blood pressure: ≥140 mmHg), which were noted in 21 (70%), 19 (63%), and 8 (27%) cases, respectively. Ten of the 30 cases (33%) were graded as severe (PSS 3) and 15 (50%) as moderate (PSS 2) poisonings. There was no fatality. Treatment included benzodi- azepines (77%), haloperidol (20%), and/or propofol (7%). Conclusion: In contrast to many other NPS, for which the fre- quency of poisonings has peaked before control actions become effective, the number of MDPV-related intoxications increased after the legislation. This is largely explained by a local outbreak among established amphetamine users that started in 2012, where MDPV became the main drug of choice. The clinical features are consis- tent with those observed by other amphetamine-like substances and the high incidence of severe intoxications suggests a lack of knowledge regarding the dose-response effect for MDPV. http://dx.doi.org/10.1016/j.toxlet.2015.08.496 P05-065 An evaluation of gastric decontamination for prevention of recurrent seizures in pediatric bupropion exposures reported to a regional poison center J. Chenoweth 1,* , D. Colby 1,2 , K. Owen 1,2 , T. Albertson 2,3 , J. Ford 2,3 , M. Sutter 1,2 1 UC Davis Medical Center, Emergency Medicine, Sacramento, United States 2 VA Northern California Healthcare System, Mather, United States 3 UC Davis Medical Center, Internal Medicine, Sacramento, United States Purpose: Bupropion ingestions including slow release prepa- rations are one of the most common causes of toxin-induced seizures in pediatric populations In order to minimize drug toxic- ity, including seizures, gastric decontamination is often performed. This can include whole bowel irrigation (WBI), activated charcoal (AC), and/or gastric lavage (GL). We aim to analyze the utility of gastric decontamination for prevention of recurrent seizures after pediatric bupropion exposure. Methods: All pediatric (age < 18yrs) patients with single agent bupropion exposure reported to the California Poison Control System between January, 2002 and December, 2012 were analyzed for reports of pre-hospital seizures.