Accepted Manuscript Title: Continuous Production of Itraconazole-based Solid Dispersions by Hot Melt Extrusion: Preformulation, Optimization and Design Space Determination Author: Justine Thiry Pierre Lebrun Chloe Vinassa Marine Adam Lauranne Netchacovitch Eric Ziemons Philippe Hubert Fabrice Krier Brigitte Evrard PII: S0378-5173(16)30937-1 DOI: http://dx.doi.org/doi:10.1016/j.ijpharm.2016.10.003 Reference: IJP 16133 To appear in: International Journal of Pharmaceutics Received date: 18-7-2016 Revised date: 30-9-2016 Accepted date: 1-10-2016 Please cite this article as: Thiry, Justine, Lebrun, Pierre, Vinassa, Chloe, Adam, Marine, Netchacovitch, Lauranne, Ziemons, Eric, Hubert, Philippe, Krier, Fabrice, Evrard, Brigitte, Continuous Production of Itraconazole-based Solid Dispersions by Hot Melt Extrusion: Preformulation, Optimization and Design Space Determination.International Journal of Pharmaceutics http://dx.doi.org/10.1016/j.ijpharm.2016.10.003 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.