585 Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Original article To evaluate the efects of Low-level laser therapy (LLLT) on wound healing of extraction socket: A systematic review Meenaz Karim 1 , Adam Husein 2 , Irfan Qamruddin 3 , Tang Liszen 4* , Mohammad Khursheed Alam 5* Abstract: Background: Low power laser therapy or low-level laser therapy (LLLT) is relatively novel and has demonstrated tremendous advantages in dentistry which includes reduction in post-surgical pain as well as swelling and also accelerates wound healing and helps in bone regeneration etc. Objective: This systematic review aimed to fnd out whether low-level laser therapy promotes tooth extraction wound healing. Materials and Methods: Literature was searched from January 2010 till 31 December 2020 using PubMed, Scopus, and Web of science. Further fndings were done from gray literature google scholar, and Research Gate using Low-level laser therapy, photobiomodulation, wound healing, extraction socket healing, cold laser, biostimulation, low-level laser irradiation, and phototherapy. Any article that reported efects of low-level laser therapy on wound healing was included. 19 studies fulflled the criteria and were included for this systematic review. Quality assessment was done for each article using Joanna Briggs Institute (JBI) checklist for analytical cross-sectional studies. Results and Discussion: Throughout the search, approximately 22,808 relevant articles were found. Out of which 50 articles fulflled the selection criteria. 31 articles were excluded because that did not fulfll inclusion criteria. 19 articles were included for this systematic review that compared the efects of low level-laser therapy on wound healing after extraction of a tooth. Conclusion: Overall, this systematic review concluded that low-level laser therapy enhanced the process of wound healing after extraction of teeth but most of the research was conducted on animals. Further research is needed to investigate the biostimulatory efects of low-level irradiation on wound healing after extraction of a tooth. Keywords: Low-level laser therapy, photobiomodulation, wound healing, extraction socket healing, cold laser, biostimulation, low-level laser irradiation, and phototherapy Correspondence: Tang Liszen drliszen@usm.my & Mohammad Khursheed Alam mkalam@ju.edu.sa 1. Meenaz Karim, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, Kota Bharu, Kelantan, Malaysia. meenaz_abhavani@yahoo.com Orcid ID: 0000-0002-0581-3102 2. Adam Husein, a. University of Sharjah, College of Dental Medicine, Department of Preventive and Restorative Dentistry. b. Prosthodontic Unit, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia. ahusein@sharjah.ac.ae Orcid ID: 0000-0001-5962-6110 3. Irfan Qamruddin, Deparment of Orthodontics, Sind Institute Of Oral Health Sciences, Jinnah Sind Medical University, Karachi, Pakistan. drirfan_andani@yahoo.com Orcid ID: 0000-0002-5179-7780 4. Tang Liszen, Oral & Maxillofacial Surgery Unit, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia. drliszen@usm.my Orcid Id: orcid.org/0000-0002-0573-3700 5. Mohammad Khursheed Alam, a. Professor, Orthodontic Division, Preventive Dentistry Department, Orthodontic Division, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia; b. Department of Dental Research Cell, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences. Chennai, India; c. Department of Public Health, Faculty of Allied Health Sciences, Dafodil lnternational University. Dhaka, Bangladesh. mkalam@ju.edu.sa; dralam@gmail.com Orcid ID: 0000-0001-7131-1752 Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 585-597 DOI: https://doi.org/10.3329/bjms.v22i3.65328 Introduction: Currently, the use of lasers in dental practices is common 1 . LLLT has made its way in dentistry and is being used for the prevention of infammatory signs and symptoms post-surgically and also gaining popularity for its ability to heal wounds faster and helps in bone regeneration 2 . LLLT is non-surgical and also have positive outcomes 3 . LLLT have also been suggested for accelerating orthodontic tooth moments and reducing the time 4 . Low level lasers are unlike other lasers which are used for cutting or ablation or coagulation of the tissues because