original article Spektrum Augenheilkd DOI 10.1007/s00717-017-0350-0 Intracameral moxifloxacin for prophylaxis of postoperative endophthalmitis Nedime Sahinoglu-Keskek · Aysel Pelit Received: 28 February 2017 / Accepted: 21 June 2017 © Springer-Verlag GmbH Austria 2017 Summary Background The aim of this study was to evaluate the rates of post-cataract-surgery endophthalmitis af- ter prophylactic intracameral moxifloxacin adminis- tration. Methods In this retrospective descriptive study, 1013 uncomplicated cataract surgeries with intraocular lens implantation were performed between March 2009 and November 2013 by one surgeon (AP). Each patient received an intracameral injection of 0.05 ml undiluted 0.5% moxifloxacin for prophylaxis of post- operative infection. Results The mean follow-up of patients was 1 year (range: 2 months to 4 years), and the mean age of the patients was 64.2 years (range: 38–99 years). Of the 1013 patients, 617 (58.6%) were women. No case of endophthalmitis occurred. Conclusion No postoperative endophthalmitis was observed after the intracameral injection of 0.5% mox- ifloxacin ophthalmic solution during routine cataract surgery. Keywords Antibiotics · Endophthalmitis · Phacoemul- sification · Prophylaxis Intrakamerale Moxifloxacingabe zur Prophylaxe der postoperativen Endophthalmitis Zusammenfassung Hintergrund Ziel der vorliegenden Studie war es, die Endophthalmitisrate nach Kataraktoperation und This study was presented as a poster at the XXXII Congress of the ESCRS, 13–17 September 2014, Excel, London, UK. N. Sahinoglu-Keskek, MD () · Prof. A. Pelit Faculty of Medicine, Adana Teaching and Medical Research Center, Baskent University, Adana, Turkey nedime_sahin@yahoo.com prophylaktischer intrakameraler Applikation von Mo- xifloxacin zu ermitteln. Methodik Im Rahmen dieser retrospektiven deskripti- ven Studie wurden 1013 unkomplizierte Kataraktope- rationen mit Intraokularlinsenimplantation zwischen März 2009 und November 2013 durch denselben Ope- rateur (AP) durchgeführt. Alle Patienten erhielten eine intrakamerale Injektion von 0,05 ml unverdünntem 0,5%igem Moxifloxacin zur Prophylaxe gegen post- operative Infektionen. Ergebnisse Die durchschnittliche Nachbeobachtungs- dauer der Patienten betrug 1 Jahr (Spannbreite: 2 Mo- nate bis 4 Jahre), und das Durchschnittsalter der Pa- tienten lag bei 64,2 Jahren (Spannbreite: 38–99 Jahre). Von den 1013 Patienten waren 617 (58,6%) Frauen. Es trat kein Fall einer Endophthalmitis auf. Schlussfolgerung Nach intrakameraler Injektion von 0,5% Moxifloxacin als Lösung zur Anwendung am Au- ge während einer Routine-Kataraktoperation trat kei- ne postoperative Endophthalmitis auf. Schlüsselwörter Antibiotika · Endophthalmitis · Phakoemulsifikation · Prophylaxe Introduction Endophthalmitis is a rare but visually damaging com- plication of cataract surgery. In 2007, the prospective, randomized European Society of Cataract and Re- fractive Surgeons endophthalmitis prophylaxis study showed a significant reduction in endophthalmitis rates with intracameral cefuroxime injection [1, 2]. Since that study, intracameral cefuroxime adminis- tration has generally been admitted, particularly in Europe [2, 3]. The number of reports on the safety of intracameral administration of moxifloxacin has increased [4–9]. Moxifloxacin seems to be a good option for endoph- K Moxifloxacin in endophthalmitis prophylaxis