_____________________________________________________________________________________________________ *Corresponding author: E-mail: khabns@sums.ac.ir; Journal of Pharmaceutical Research International 17(6): 1-13, 2017; Article no.JPRI.35243 Previously known as British Journal of Pharmaceutical Research ISSN: 2231-2919, NLM ID: 101631759 Synthesis of Some Novel Semicarbazone and Thiosemicarbazone Derivatives of Isatin as Possible Biologically Active Agents Masoumeh Divar 1,2 , Ali Khalafi-Nezhad 2 , Kamiar Zomorodian 3 , Razieh Sabet 4 , Zahra Faghih 5 , Maryam Jamali 4 , Hasti Pournaghz 4 and Soghra Khabnadideh 1* 1 Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 2 Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran. 3 Basic Sciences in Infectious Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 4 Faculty of Pharmacy, International Branch, Shiraz University of Medical Sciences, Shiraz, Iran. 5 Cancer Immunology Group, Shiraz Institute for Cancer Research, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran. Authors’ contributions This work was carried out in collaboration between all authors. Authors MD and AKN designed, synthesized and analyzed the data of the Isatin derivatives. Authors KZ, RS, ZF, MJ, HP and SK prepared the antimicrobial and cytotoxicity tests. Authors MD and SK wrote the paper. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2017/35243 Editor(s): (1) Syed A. A. Rizvi, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, USA. Reviewers: (1) Prakashanand Caumul, University of Mauritius, Mauritius. (2) Ahmed Mohammed Abu-Dief Mohammed, Sohag University, Egypt. (3) Chong Leong, Gan, Universiti Malaysia Perlis, Malaysia. Complete Peer review History: http://www.sciencedomain.org/review-history/20102 Received 1 st July 2017 Accepted 14 th July 2017 Published 18 th July 2017 ABSTRACT Aims: The development of new beneficial agents is one of the crucial aims in medicinal chemistry. Isatin is considered as a vital class of bioactive compounds exhibiting different biological activities. A series of nine new Semicarbazone (12a-i) and six new Thiosemicarbazone (14a-c, 14f-h) derivatives of isatin were prepared. Original Research Article