~ 366 ~ International Journal of Applied Dental Sciences 2021; 7(2): 366-369 ISSN Print: 2394-7489 ISSN Online: 2394-7497 IJADS 2021; 7(2): 366-369 © 2021 IJADS www.oraljournal.com Received: 07-02-2021 Accepted: 09-03-2021 Dr. Aditya Sharma Post Graduate Student, Department of Periodontology, Subharti Dental College, Swami Vivekanand Subharti University, NH-58, Meerut, Uttar Pradesh, India Dr. Mayur Kaushik Professor and Head, Department of Periodontology, Subharti Dental College, Swami Vivekanand Subharti University, NH-58, Meerut, Uttar Pradesh, India Dr. Nazar Rana Reader, Department of Periodontology, Subharti Dental College, Swami Vivekanand Subharti University, NH-58, Meerut, Uttar Pradesh, India Dr. Soundarya Singh Senior Lecturer, Department of Periodontology, Subharti Dental College, Swami Vivekanand Subharti University, NH-58, Meerut, Uttar Pradesh, India Corresponding Author: Dr. Aditya Sharma Post Graduate Student, Department of Periodontology, Subharti Dental College, Swami Vivekanand Subharti University, NH-58, Meerut, Uttar Pradesh, India Placentrex gel used as a surgical wound healing agent: A case report Dr. Aditya Sharma, Dr. Mayur Kaushik, Dr. Nazar Rana and Dr. Soundarya Singh DOI: https://doi.org/10.22271/oral.2021.v7.i2f.1232 Abstract Gingival enlargement is an inflammatory response to plaque present on tooth surfaces or due to factors like drugs and several systemic conditions. In cases where the local factors are responsible and subgingival scaling and root planing do not help, gingivectomy/gingivoplasty is performed which creates a raw wound which heals slowly. Since surgical practice primarily depends upon the healing of these wounds without serious complication and infection occurring, to increase the rate of healing of a postoperative surgical wound, placental extract gel has been used as a therapeutic agent because it has unique pharmacological effects like enhancement of wound-healing, anti-inflammatory action, analgesic effect etc. A variety of substances with biological and therapeutic activity present in human placenta have been isolated and identified as hormones, proteins, glycosaminoglycans, nucleic acids, polydeoxyribonucleotides (PDRNs) etc. which therefore play a major role in the faster healing of a surgical wound. Keywords: placenta, healing, gingivectomy, gingivoplasty Introduction Gingival enlargement (hyperplasia) is a condition often occurring due to plaque on the tooth surface, systemic intake of drugs and also due to some systemic conditions. If the enlargement is due to local factors, then removal of the same by subgingival scaling will cause the regression of the enlargement. But sometimes, the enlargement remains even after repeated scaling and root planing. In such instances, the gingiva has to be excised surgically and the wound produced by gingivectomy/gingivoplasty is a raw wound which heals by secondary intention with a slower rate. It takes six weeks for the epithelization to be completed. During this period, patients experience a lot of pain and discomfort [1] . The surgical practice primarily depends upon the healing of wounds without serious complication and infection occurring. It accounts for considerable patient morbidity, discomfort, and prolonged hospitalization [2] . so, the postoperative care plays a major role for a better healing and for that several methods have been employed over the years. The placenta is now viewed by many as a substance which will revolutionise modern medicine. It increases the healing by stimulating the nervous regulation, hormonal regulation, & immune system regulation and gives resistance to the body which will help in increasing collagen synthesis and improving tensile strength of the healing tissue [3, 4] . Use of placenta as a therapeutic agent has been prevalent for a long time because it is an immunologically privileged organ and has unique pharmacological effects like enhancement of wound-healing, anti-inflammatory action, analgesic effect etc. A variety of substances with biological and therapeutic activity present in human placenta, have been isolated and identified as hormones, proteins, glycosaminoglycans, nucleic acids, polydeoxyribonucleotides (PDRNs) etc. [3] . The composition of placental extract thus depends on the method of its preparation. In many countries, intramuscular and topical use of the extract for burn injuries, chronic wounds and as postsurgical dressing is an age old practice [3] .