_____________________________________________________________________________________________________ *Corresponding author: E-mail: suuress@gmail.com; Journal of Pharmaceutical Research International 33(20A): 56-63, 2021; Article no.JPRI.66831 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Risk Factor Assessment of Helicobacter pylori Infection in a Rural Community of People with Gastritis: A Community Based Cross-Sectional Study Suresh Jaiswal 1* , Bishnu Raj Tiwari 2 and Dinesh C. Sharma 1 1 School of Life and Allied Health Science, Glocal University, India. 2 School of Health and Allied Sciences, Pokhara University, Nepal. Authors’ contributions This work was carried out in collaboration among all authors. Author SJ designed the study, performed the statistical analysis, wrote the protocol, managed the literature searches and wrote the first draft of the manuscript. Authors BRT and DCS managed the analyses of the study. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i20A31348 Editor(s): (1) Dr. Giuseppe Murdaca, University of Genoa, Italy. Reviewers: (1) Anthony N. Umo, University of Uyo, Nigeria. (2) Faisal Aziz, The Hormel Institute and University of Minnesota, USA. Complete Peer review History: http://www.sdiarticle4.com/review-history/66831 Received 20 January 2021 Accepted 24 March 2021 Published 03 April 2021 ABSTRACT Aim: The purpose of this study was to detect the incidence and risk factors of H. Pylori infections in patients with gastritis. Study Design: A community-based cross-sectional study. Place and Duration of Study: Mahagadhimai-5, Province 2 in a rural setting of Nepal from November 2019 to March 2020. Methodology: Stool samples were collected from the gastritis patients and were subjected to detection of the H. pylori stool antigen following the procedures recommended by the manufacturer. A questionnaire was completed by the investigators with the cooperation of each participant for the potential risk factors as designed and completed. Results: Out of 150 participants, 82 (54.7%) were female and 68 (45.3%) were male participants. Out of 150 participants, 32.7% (49) were positive for H. pylori antigen. No significant association Original Research Article