Jemds.com Review Article J Evolution Med Dent Sci / eISSN - 2278-4802, pISSN - 2278-4748 / Vol. 9 / Issue 51 / Dec. 21, 2020 Page 3873 Review on Assessment of Response of Neo-Adjuvant Chemotherapy in Patients of Carcinoma Breast by High Frequency Ultrasound Sajika Pramod Dighe 1 , Raju K. Shinde 2 , Sangita Jogdand Shinde 3 , Anupam Anand 4 1, 2, 4 Department of Surgery, Jawaharlal Nehru Medical College, DMIMS, Sawangi, Wardha, Maharashtra, India. 3 Department of Pharmacology, Jawaharlal Nehru Medical College, DMIMS, Sawangi, Wardha, Maharashtra, India. ABSTRACT Neo-Adjuvant Chemotherapy (NACT) is used in patients with breast cancer to reduce tumour focus, metastatic risk, and patient mortality. Neoadjuvant treatment of breast cancer has become established as a safe and often effective therapeutic approach of choice for larger primary and for locally advanced breast cancer. Neoadjuvant approach offers the advantages of down staging the disease, potentially reducing the extent of surgery and in an era of individualisation of therapy, tests the efficacy of therapy administered to patients. The preoperative setting is also an effective way to study the activity of novel agents or therapeutic combinations in vivo against human breast cancer. For new therapies, preoperative trials avoid the issue of adaptive resistance and pre-treatments that can be problematic in the advanced disease setting. Monitoring NAC effects is necessary to capture resistant patients and stop or change treatment. The existing methods for evaluating NAC results have some limitations. Quantitative ultrasound information can characterise the tumour’s pathological response better and at an earlier stage of therapy than the assessment of the reduction of its dimensions. The introduction of statistical parameters of ultrasonic backscatter to monitor the effects of chemotherapy can increase the effectiveness of monitoring and contribute to a better personalisation of NAC therapy. KEY WORDS Carcinoma Breast, Locally Advanced Breast Cancer, Neoadjuvant Chemotherapy, Anterior Chemotherapy, High Frequency Ultrasound, Ultrasonography. Corresponding Author: Dr. Raju K. Shinde, Department of Surgery, Jawaharlal Nehru Medical College, DMIMS, Sawangi, Wardha, Maharashtra, India. E-mail: raju.shinde95@gmail.com DOI: 10.14260/jemds/2020/849 How to Cite This Article: Dighe SP, Shinde RK, Shinde SJ, et al. Review on assessment of response of neo-adjuvant chemotherapy in patients of Carcinoma breast by high frequency ultrasound. J Evolution Med Dent Sci 2020;9(51):3873- 3880, DOI: 10.14260/jemds/2020/849 Submission 31-08-2020, Peer Review 27-10-2020, Acceptance 03-11-2020, Published 21-12-2020. Copyright © 2020 Sajika Pramod Dighe et al. This is an open access article distributed under Creative Commons Attribution License [Attribution 4.0 International (CC BY 4.0)]