https://scilett-fsg.uitm.edu.my/ Vol. 15(2) JUNE 2021 ISSN: 1675-7785 eISSN: 2682-8626 Copyright© 2021 UiTM Press. DOI: 10.24191/sl.v15i2.13835 135 Science Letters Vol. 15(2) JUNE 2021 Proton Magnetic Resonance Spectroscopy ( 1 H-MRS) in Studies of Glaucoma: A Scoping Review Liyana Musa 1* , Sabrilhakim Sidek 2* , Firdaus Yusof @ Alias 3* , Mohammad Hanafiah 4 , Azlan Azha Musa 5 and Mazuin Mohd Razalli 2 1 Department of Diagnostic Imaging and Radiotherapy, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia 2 Department of Radiology, Faculty of Medicine, Universiti Teknologi MARA, Kampus Sungai Buloh, 47000 Sg. Buloh, Selangor, Malaysia 3 Department of Optometry and Visual Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia 4 Radiology Department, Sunway Medical Centre, Bandar Sunway, 47500 Selangor, Malaysia 5 Department of Ophthalmology, Faculty of Medicine, Universiti Teknologi MARA, Kampus Sungai Buloh, 47000 Sg. Buloh, Selangor, Malaysia Corresponding authors: liyanamusa@iium.edu.my, sabrilhakim@uitm.edu.my, yfirdaus@iium.edu.my Received: 8 April 2021; Accepted: 5 June 2021; Published: 15 June 2021 ABSTRACT Glaucoma is a disease that is chronic in nature and indistinctive at an early stage, leading to late detection. It has become a major public health problem and a leading cause of irreversible blindness worldwide. The proton magnetic resonance spectroscopy ( 1 H-MRS), of late, has been utilised to evaluate metabolites concentration in the brain, especially for detecting neurodegenerative disease. Considering that glaucoma is a neurodegenerative disease, studies on the concentration of metabolites using 1 H-MRS in glaucoma patients could be investigated. This scoping review aims to examine the extent, range, and nature of studies on the 1 H-MRS technique in glaucoma disease. The literature search was conducted using MEDLINE, CINAHL and SCOPUS, dated from 2000 until 2019. Studies on glaucoma using 1 H-MRS were considered. Any processing method used to characterise the metabolite concentration generated by the 1 H-MRS