Submit Manuscript | http://medcraveonline.com Abbreviations: DBS, dodecylbenzene sulfonate; PDMS, poly- dimethylsiloxanes; PEG, polyethyleneglycol; PLA, polylactic acid; PLGA, poly (lactic-co-glycoid acid); PNIPAAm, poly (N-isopropy- -lacrylamide); PPy, poly pyrrole; PS, poly styrene; PSS, polysodium styrene sulfonate; QAS, quaternary ammonium salt; SAM, self-as- sembled monolayers; PDMS, polydimethylsiloxane Introduction The aim of this mini review was zoom in the perspective and feasible methods to produce nanopatterned polymers surfaces and to collect their some properties. This has opened new possibilities for making affordable polymer products with functional nanopatterned surfaces. While a variety of approaches to create hydrophobic/ superhydrophobic surfaces have been developed, 1–5 there are still restrictions on their widespread use due to the cost, number of processing steps, limits on the manufacturable area, durability, instrumentation required, etc. This has led to the development of inexpensive and reliable techniques for the commercial production of hydrophobic layers. Electrochemical methods have been used to prepare a Ni based nanostructured surface coupled with a polydimethylsiloxane (PDMS) monolayer using spin – coating. 6 The surface hydrophobicity increased by about 30% in comparison to the Ni surface only and could be modifed to enhance the adhesion of ordered biomolecules or the self-assembly of monolayers. Alternative simple methods included the fabrication of a shark-skin-like patterned PDMS modifed with carbon nanotubes to form a polymeric superhydrophobic flm. 7 A high viscosity paste (comprised of 10 wt % multi walled carbon nanotubes dispersed into PDMS) was placed between two rollers, and the paste was transferred as a smooth flm (with less than 300nm roughness) onto the roll with the high rotational speed. 7 A spin-coating method has been used to form a biomimetic interface from melanin whose electric signal transduction can be modifed. 8 High density plasma processing was employed to create a nanotextured superhydrophobic transparent poly (methyl methacrylate) surface. 9 By appropriate tuning of the plasma conditions, either random or ordered hierarchical structures of high aspect ratio and surface area could be reproducibly created. Such plasma treated polymeric surfaces have been evaluated as substrates for effciently controlling the wettability, biomolecules immobilization, and cell adhesion of the surface, paving the way to a wide spectrum of applications. A three-dimensional plasma micro-nanotextured cyclo-olefn-polymer surfaces has been used for biomolecules immobilization because of its environmentally stable superhydrophobic and superoleophobic properties. 10 Plasmas could also be used to deposit fuorocarbons on a cyclo-olefn polymer to enhance hydrophobicity 11 with good adhesion and effective surface protection reducing plastic deformation. A micro reactive ion-etching method has been used to prepare nanotextured flms from PDMS for enhanced cancer cell isolation. 12 Slippery liquid-infused porous surfaces show great promise for preventing bioflm formation owing to their low surface energy in combination with their self-cleaning properties. 13 Li and co-workers demonstrated a novel hydrophobic liquid-infused porous poly (butyl methacrylate-co-ethylene dimethacrylate) surface with bacteria- resistance in BM2 mineral, which had medium and long-term stability in aqueous environments with Pseudomonas aeruginosa. 13 Highly enhanced solid-state thermochromism was observed in regio-regular poly (3-hexylthiophene) when deposited on a superhydrophobic polymer-SiO 2 nanocomposite coating without reducing the superhydrophobicity. 14 Peng et al. 15 have quantifed the volume and surface hydrophilicity of a range of water- swollen dense polymer brushes as a function of temperature. They used thermo responsive poly (N-isopropylacrylamide) and poly (di(methoxyethoxy) ethyl methacrylate), strongly hydrophilic poly (N, N-dimethylacrylamide) and poly (oligo (ethylene glycol) methacrylate), and weakly hydrophilic poly (2-hydroxyethyl MOJ Poly Sci. 2017;1(4):141‒145. 141 © 2017 Orinak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially. Functionality of nanopatterned polymer surfaces Volume 1 Issue 4 - 2017 Orinak A, 1 Orinakova R, 1 Macko J, 1,2 Petrus O, 1 Levoca S 1 1 Department of Physical Chemistry, University of P J Safarik in Kosice, Slovakia 2 Department of Physical and Theoretical Chemistry, Komensky University Bratislava, Slovakia Correspondence: Orinak A, University of P J Safarik in Kosice, Srobarova 2, Kosice, Slovakia, Tel 004210552342321, Email andrej.orinak@upjs.sk Received: April 17, 2017 | Published: August 28, 2017 Abstract The different methods of the nanopatterning of polymer layers, UV laser ablation, plasma depositing technique, electrochemical deposition and soft lithography are discussed as methods of surface patterning. The different surface functionalities are described, especially the effects of increased surface hydrophobicity/ superhydrophobicity created by coating substrates with low surface energy material coupled with controlling the polymer surface roughness at both micro- and nano- scale, with many of these hydrophobic layers representing bio-inspired surfaces. Cell adhesion onto nanopatterned polymer surfaces, bacteria and biomolecules immobilization, and cancer cell isolation are discussed as switchable functionalities. A new field is self-assembled monolayers formed from polymers, which can modulate a surface functionality from hydrophilicity to hydrophobicity, forming highly ordered molecular structures to bind different biomolecules and to create stimuli-responsive polymer systems. These polymers have the potential to tune surface wettability to a desired level with a controlled surface structure and smoothness. Examples are described of rotaxenes which are polymeric self-assembled monolayers which can form molecular devices/nanodevices. Keywords: nanopatterning, polymer, surface, functionality MOJ Polymer Science Mini Review Open Access