116 Summer 2023. Vol 32. Num 2 * Corresponding Authors: Negar Motaghi-Dastjerdi Address: Department of Pharmacognosy and Pharmaceutcal Biotechnology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran. Tel: +98 (912) 2936592 E-Mail: Motaghi.n@iums.ac.ir Research Paper Evaluaton of the Efects of Diferent Crosslinking Technologies on Hyaluronic Acid Behavior-study of Five Hyaluronic Acid Gels Available in Iran Market 1. Department of Pharmacology and Toxicology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran. 2. Department of Pharmacognosy and Pharmaceutcal Biotechnology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran. Mehdi Aghsami 1 , * Marjan Shariatpanahi 1 , Hamed Montazeri 2 , * Negar Motaghi-Dastjerdi 2 Background The rheologic, mechanical, and pharmacological characteristcs of hyaluronic acid (HA) gels vary in terms of their specifc crosslinking technologies. Objectve To evaluate the various characteristcs of selected HA gels available in Iran, using simple, inex- pensive, and reproducible experimental tests are necessary to beter understand their appropriateness for specifc indicatons. Methods The HA gels produced by various crosslinking technologies were evaluated by three experi- ments, including cohesivity, resistance to stretch, and microscopic examinaton. The gels subjected to these experiments in this study included Neuramis, Desirial, Belotero, Restylane, and Juvéderm. Results We found that cohesivity was diferent among the gels so that Desirial was the least cohesive and Belotero was the most cohesive gel. Other HA gels were observed as partally cohesive. The resistance to stretch test confrmed the cohesivity results and Belotero had the most signifcant resistance. Micro- scopic examinaton of the HA gels showed HA partcles of varying distributon and size. Belotero and Desirial were the gels with no partcles visible under the microscope. Conclusion Simple and inexpensive laboratory tests help to understand the way that they can afect the specifc gel performance, and may be benefcial for physicians to decide on the best product for a par - tcular therapeutc indicaton. A B S T R A C T Keywords: Hyaluronic acid, Gel, Filler, Crosslinking Received: 12 Dec 2022 Accepted: 05 Apr 2023 Available Online: 01 Jul 2023 Citaton Aghsami M, Shariatpanahi M, Montazeri H, Mottaghi-Dastjerdi N. [Evaluation of the Effects of Different Crosslinking Technologies on Hyaluronic Acid Behavior-study of Five Hyaluronic Acid Gels Available in Iran Market (Persian)]. Journal of Guilan University of Medical Sciences. 2023; 32(2):116-127. https://doi.org/10.32598/JGUMS.32.2.2078.1 https://doi.org/10.32598/JGUMS.32.2.2078.1 Use your device to scan and read the article online Marjan Shariatpanahi Address: Department of Pharmacology and Toxicology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran. Tel: +98 (21) 44606181 E-Mail: Shariatpanahi.m@iums.ac.ir [ DOI: 10.32598/JGUMS.32.2.2078.1 ] [ Downloaded from journal.gums.ac.ir on 2023-12-01 ] 1 / 12