Results: The results showed that total 1,147 variants were selected under recessive inheritance model. Whereas there were 39,330 variants selected under the dominant inheri- tance model. After comparing with the alleles listed in the 1000 Genomes Project, 1,626 variants that exhibited inheri- tance in the family but not seen in other known data bases were identified for those in accordance with dominant inheritance model. Besides, 3 non-synonymous exonic SNVs were resequenced in 5 individuals of the schizophrenia multiplex family by Sanger sequencing. One of these 3 non-synonymous exonic SNVs were replicated in other 7 multiplex families from TSLS with higher allele frequency within TSLS than Taiwan biobank. The other 2 non-synon- ymous exonic SNVs were private to this schizophrenia multiplex family. Discussion: Our findings demonstrated the utility of NGS in identifying inherited rare genetic variants that are potentially associated with multiplex schizophrenia. Our use of a multiplex family can help exclude those variants due to typing error, or de novo mutations, and hence select those with high-penetrating susceptibility genetic variants for schizophrenia. In particular, one of the 3 non-synon- ymous exonic SNVs was identified in other 7 multiplex families from TSLS. The other 2 private non-synonymous exonic SNVs and remaining intronic SNVs require further evaluation in context of supporting data. This may lead to discovery if rare but inheritable susceptibility variants for schizophrenia and their underlying pathophysiology. Disclosure: Nothing to disclose. http://dx.doi.org/10.1016/j.euroneuro.2017.08.410 M104. EXAMINING ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) INATTENTION SYMPTOMS AS ANTE- CEDENTS OF PSYCHOSIS RISK IN 22Q11.2 DELETION SYNDROME (22Q11.2DS) Maria Niarchou n ,1 , Jacob Vorstman 2 , Maude Schneider 3 , Stephan Eliez 3 , Marco Armando 4 , Donna McDonald-McGinn 5 , Carrie Bearden 6 , Vandana Shashi 7 , Stephen Hooper 7 , Marianne Van Den Bree 1 , Michael Owen 8 , Raquel E. Gur 9 , Naomi Wray 10 , Anita Thapar 1 1 Cardiff University 2 Rudolf Magnus Institute 3 University of Geneva 4 University of Rome La Sapienza 5 Childrens Hospital of Philadelphia 6 University of California Los Angeles 7 Duke University 8 MRC Centre for Neuropsychaitric Genetics and Genomics, Cardiff University 9 University of Pennsylvania 10 The University of Queensland Background: 22q11.2 Deletion Syndrome (22q11.2DS) is associated with high risk for developing schizophrenia in adulthood while Attention Deficit Hyperactivity Disorder (ADHD) constitutes the most frequent diagnosis in child- hood. Individuals with 22q11.2DS show marked inattention symptoms. Interestingly, schizophrenia is also characterized by attentional deficits. This raises the question of whether childhood inattention is an antecedent of psychosis in 22q11.2DS. This is the first longitudinal study to examine whether childhood inattention is associated with the later emergence of Psychotic Experiences (PEs) and psychosis spectrum disorders in 22q11.2DS. Methods: 294 individuals (mean age (SD):15.9(5.8)) com- pleted assessments on psychotic symptoms and ADHD at two time points and did not report PEs at time 1(T1). Results: Inattention symptoms and ADHD diagnosis at T1 were associated with PEs at T2 when adjusting for age, sex, IQ and assessment differences (Odds Ratio: 1.18, p = 0.02). ADHD diagnosis at T1 was also associated with psychosis spectrum disorder at T2 (Odds Ratio: 4.8, po0.001). Discussion: This is the first study to examine the long- itudinal associations between ADHD and psychosis in 22q11.2DS. Our findings support an important role of ADHD inattention symptoms in the development of psychosis in 22q11.2DS. Disclosure: Nothing to disclose. http://dx.doi.org/10.1016/j.euroneuro.2017.08.411 M105. POTENTIAL ASSOCIATION OF MIR-137 WITH AGE OF ONSET OF SCHIZOPHRENIA Gabriela Chavarria-Soley n ,1 , Javier Contreras 2 , Patricia Bolaños-Palmieri 3 , Daniela Ugalde-Araya 3 , Alejandro Avila-Aguirre 3 , Christopher Mairena-Acuña 2 , Henriette Raventos 3 1 Escuela de Biologia, Universidad de Costa Rica 2 Centro de Investigación en Biología Celular y Molecular 3 Centro de Investigación en Biología Celular y Molecular and Escuela de Biología, UCR Background: MicroRNAs (miRNAs) play a vital role in neuro- development and neuronal processes by regulating the activity of multiple genes. Noncoding variants in the miR-137 gene locus have been reported to increase the risk of schizophrenia. This microRNA has been shown to be involved in different brain processes necessary for neurogenesis, which is an important factor in schizophrenia. Additionally, several of the confirmed or predicted target genes for miR-137 have been associated with schizophrenia risk. Methods: In the present study, we sequenced the miR-137 gene (including the upstream and downstream region) in 52 Costa Rican trios, consisting of individuals diagnosed with schizophrenia and their parents. A TDT test was performed for the two detected variants: the schizophrenia-associated SNP rs1625579 and a previously reported VNTR located upstream of miR-137. Results: No association was found between any rs1625579 allele and schizophrenia (X2 = 1, p = 0.32). The minor allele frequency (MAF; corresponding to the C allele) in the Costa Abstracts S1012