International Journal of Sciences: Basic and Applied Research (IJSBAR) ISSN 2307-4531 (Print & Online) http://gssrr.org/index.php?journal=JournalOfBasicAndApplied --------------------------------------------------------------------------------------------------------------------------- 126 The Investigating of Photoplethysmogram Waveform Amplitude Changes: Aging and Atherosclerosis Yousef Qawqzeh a *, Loai Kayed b , Mohammad Otoom c , Mafawez Alharbi d , Fakhri Alam Khan e a,b,c,d Computer Science& Information Technology Department – College of Science – Majmaah University Zulfi, Riyadh , Saudi Arabia b Institute of Management Sciences, Peshawar, Pakistan a-d Email: y.qawqzeh@mu.edu.sa e Email: fakhri.alam@imsciences.edu.pk Abstract This paper focuses on the analysis of PPG waveform amplitude changes. As PPG signal reflects blood volume changes, studying its (peaks and valleys) amplitudes changes is highly appreciated. The results showed a strong positive relationship between age and RI index (R square = 0.657) and a strongly negative relationship between age and systolic peak index (R square = -0.651). The obtained results underline the importance of studying PPG's (peaks and valleys) amplitude changes and their association with age and atherosclerosis. The association between aging, atherosclerosis, arterial stiffness and PPG's morphology can provide a fruitful tool towards disease prevention and early-risk prediction. The increment of systolic peak as we age might indicate the present of atherosclerosis and the start of arterial stiffness. In addition, the increment of RI index as we age, may contribute to the process of high-risk atherosclerosis prediction and therefore approaching risk prevention. Keywords: PPG; RI; Systolic Peak; Atherosclerosis; Age. ------------------------------------------------------------------------ * Corresponding author. brought to you by CORE View metadata, citation and similar papers at core.ac.uk provided by GSSRR.ORG: International Journals: Publishing Research Papers in all Fields