International Journal of Research in Medical Sciences | January 2017 | Vol 5 | Issue 1 Page 177 International Journal of Research in Medical Sciences Manorenj S et al. Int J Res Med Sci. 2017 Jan;5(1):177-180 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Original Research Article Cerebral sinus venous thrombosis Sandhya Manorenj*, Sudhaker Barla INTRODUCTION Ribes et al first discovered CSVT in 1825 on autopsy cases. CSVT affects predominantly younger people with female gender predominance. 1 CSVT is considered to be a multifactorial condition associated with inherited and acquired risk factors. Inherited risk factors include hyperhomocystenemia, factor V Leiden mutation, protein C, protein S and antithrombin III deficiency and positive anti-cardiolipin and antiphospholipid antibodies. 1,2 Acquired risk factors include central nervous system infections, head trauma, brain tumor, systemic vasculitis, hematological conditions, nephrotic syndrome, pregnancy and puerperium and dehydration. The purpose of present study is to investigate the prevalence, pattern and risk ABSTRACT Background: Intracranial Sino venous occlusive disease is an infrequent condition and accounts only 0.5-1% of all strokes. Objective of the study was to know the prevalence, pattern and risk factors involved in patients of cerebral sinus venous thrombosis (CSVT). Methods: Hospital databases were searched retrospectively and patients diagnosed with CSVT from December 2014 to February 2016 were identified. Data on clinical presentation, risk factor, cerebral sinus involved, hospital stay and outcome were analyzed. Results: Fifteen patients (3.4%) were identified as CSVT out of a total acute stroke case of 430. Mean age of patients was 31 years and 11 (73.3%) were males. The presenting symptoms included headache (n=14), altered sensorium (n=1) and seizures (n=5); signs included hemi paresis (n=4), papilledema (n=8) and bilateral VI nerve palsy (n=3). Majority had aseptic CSVT (n=14), and one patient had septic CSVT associated with tuberculous meningitis (TBM). Radiological findings included brain parenchyma involvement (n=8), subdural hematoma (SDH) (n=1), subarachnoid haemorrhage (SAH) (n=1) and normal brain parenchyma (n=5). Multiple cerebral sinuses were involved in seven patients. Most common site of CSVT was observed in sigmoid sinus. Risk factors included hyperhomocystenemia (n=3), protein S deficiency (n=8), protein C deficiency (n=6) and antithrombin III deficiency (n=3) as primary hypercoagulable state. ANA positive was observed in one patient and four had history of alcohol use. All fifteen patients received low molecular weight heparin (LMWH) for 1 week along with bridging oral anticoagulant. None of the patients required intrasinus thrombolysis and decompression surgery. Average hospital stay was 9 days. All had modified Rankin scale (MRS) ≤ 2 at 6 months follow up. Conclusions: Prevalence of CSVT is higher than that reported from Asian studies. Younger age and male predominance was observed. Protein S deficiency was the major risk factor for CSVT. Keywords: Cerebral sinus venous thrombosis, India Department of Neurology, Employees State Insurance Corporations, Superspeciality Hospital, Sanath Nagar, Hyderabad, India Received: 22 October 2016 Revised: 31 October 2016 Accepted: 26 November 2016 *Correspondence: Dr. Sandhya Manorenj, E-mail: drsandhyamanorenj@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20164544