Biomedicine: 2023; 43(1) Supplementary issue: 104-107 January-February 2023 DOI: https://doi.org/10.51248/.v43i1.1754 Biomedicine- Vol. 43 No. 1 Supplementary issue: 2023 Research article Study of uric acid and microalbuminuria in preeclampsia and normal pregnant women Sonia Jindal 1 , Sunita Manhas 1 , Parmal Saini 2 , Narendra Kumar Sah 3 1 Department of Medical Biochemistry, Maharishi Markandeshwar University, Mullana, Ambala, 133207, Haryana, India 2 Department of Community Medicine, Aadesh Medical College and Hospital, Mohri Tehsil, Shahabad, Kurukshetra, 136135, Haryana, India 3 Department of Biochemistry, Maharishi Markandeshwar, Medical College & Hospital, Kamarhati, Solan, 173229, Himachal Pradesh, India (Received: April 2022 Revised: January 2023 Accepted: February 2023) Corresponding author: Narendra Kumar Sah. Email: sumanshah2007@gmail.com ABSTRACT Introduction and Aim: Pregnancy is complicated by the hypertension disease known as pre-eclampsia. The development of hypertension to a level of 140/90 mmHg or greater in the presence of proteinuria after the 20th week of gestation characterises this condition, a multisystem disorder with an unclear cause. Uric acid and microalbuminuria were assessed in preeclamptic women (PW) and normal pregnant women (NPW). Materials and Methods: For the present study 120 women (60 NPW and 60 PW) were selected from the hospital at Mullana, Ambala, Haryana. The level of uric acid and microalbuminuria were estimated in all subjects. Results: Preeclamptic women had microalbuminuria levels that were substantially (p<0.001) greater than those of normal pregnant women, and their uric acid levels were significantly (p<0.001) higher. Conclusion: Preeclampsia patients had significantly higher uric acid and microalbuminuria levels than normal pregnant women. We deduced from the study that uric acid and microalbuminuria can be helpful in diagnosing preeclampsia risk. Keywords: Uric acid; microalbuminuria; preeclampsia; hypertension. INTRODUCTION ne of the frequent pregnancy problems is preeclampsia. Preeclampsia affects 4-5% of pregnant women, and its pathogenesis is unknown (1,2). At the 20th week of pregnancy, preeclampsia manifests as hypertension, proteinuria, dyslipidaemia, an intensified systemic inflammatory response, and oedema. It is also associated with thrombocytopenia, disseminated intravascular coagulation, and liver damage in its most severe form (3,4). The primary by-product of purine metabolism is uric acid. Fay stated in 1990 that an increase in the disintegration of placental cells may result from an overproduction of uric acid (5). Jeyabalan et al., (6) reported that elevated levels of serum uric acid in preeclamptic as a result of reduced renal clearance. Pre-eclampsia and gestational hypertension patients share a number of risk factors. The extent of placental cell apoptosis and the severity of the illness are both reflected in an elevated uric acid level. such as older mothers, obesity, low serum Ca and Mg levels, and higher uric acid concentrations(7). It has been suggested that either a reduction in uric acid excretion or an increase in uric acid synthesis is what causes the hyperuricemia in preeclampsia (5,6). In the absence of clinically evident nephropathy, urine albumin excretion above normal levels are regarded as evidence of microalbuminuria (8-10). Urinary albumin levels between 30 and 300 mg/24 hours are considered to indicate the presence of microalbuminuria (11). One of the defining characteristics of preeclampsia is microalbuminuria. It is confirmed that abnormalities in renal function are present in some otherwise symptom-free patients in whom pre-eclampsia would subsequently develop by the presence of microalbuminuria. Microalbuminuria levels in the early stages of pregnancy have a significant negative predictive value as indicators of preeclampsia (12). In pregnancy, persistent microalbuminuria has substantial diagnostic significance as a potential indicator of developing PE because it suggests a high likelihood of kidney glomerular filtration capacity impairment (13). MATERIALS AND METHODS The current study was conducted in Maharishi Markandeshwar Institute of Medical Sciences and Researches, Mullana Ambala, Haryana, India, which had 120 participants (60 healthy pregnant women and 60 preeclamptic women), in a hospital setting. The institution's ethical review board had approved the study. Women who were 20 weeks or more gestation and had a systolic blood pressure of less than 140 mm Hg and a diastolic blood pressure of less than 90 mm Hg were deemed to have hypertension- preeclampsia. The research also excluded participants who refused to take part or who had already given O 104