ORIGINAL ARTICLE A cross-sectional examination of factors associated with compassion satisfaction and compassion fatigue across healthcare workers in an academic medical centre Chizimuzo T. C. Okoli, 1 Sarret Seng, 1 Janet K. Otachi, 2 Jacob T. Higgins, 1 Jessica Lawrence, 3 Amanda Lykins 3 and Elizabeth Bryant 3 1 University of Kentucky College of Nursing, 2 University of Kentucky College of Social Work, and 3 UK Healthcare, Lexington, Kentucky, USA ABSTRACT: Compassion satisfaction (CS) among healthcare professionals is a sense of gratification derived from caring for their suffering patients. In contrast, compassion fatigue, often a consequence of burnout (BO) and secondary traumatic stress (STS), is detrimental to healthcare professionals’ productivity and patient care. While several studies have examined CS, BO, and STS among healthcare professionals, the majority have assessed samples in specific disciplines. However, the comparative differences in these factors by discipline or work setting are not well known. The aims of this study were to examine the differences in CS, BO, and STS by discipline and work setting, and to assess demographic, work-related, and behavioural factors associated with these outcomes. An electronic survey was administered (N = 764) at a large academic medical centre in the southeast United States. Questions elicited demographic variables, work- related factors, behavioural/lifestyle factors, experience with workplace violence, and the Professional Quality of Life Scale. Findings of the study determined that the rates of CS, BO, and STS vary across healthcare disciplines and work settings. Demographic, work-related, behavioural, and work setting (i.e., experience of workplace violence) factors were differentially associated with experiences of CS, BO, and STS. The results of the study suggest two potential areas for research, specifically workplace violence and sleep quality as a means of further understanding reduced CS and increased BO and STS among healthcare workers. These findings have important implications for future research and policy interventions to enhance healthcare workers’ health and safety. KEY WORDS: compassion satisfaction, burnout, healthcare professionals. Correspondence: Chizimuzo T. C. Okoli, Tobacco Treatment Services and Evidence-Based Practice, Behavioral Health and Wellness Environments for Living and Learning, University of Kentucky College of Nursing, 517 College of Nursing Building, Lexington, KY 40536-0232 USA. Email: ctokol1@uky.edu Authorship statement: C. Okoli conceptualized the study, analysed the data, and drafted the results and discussion sec- tions. S. Seng and J. Otachi drafted the initial introduction and methods sections. J. Higgins and E. Bryant assisted in data col- lection, reviewed the manuscript, and provided important con- tributions throughout. A. Lykins drafted the Abstract section, reviewed the manuscript, and provided intellectual contribu- tions. J. Lawrence assisted in data collection, drafting the relevance to practise and implications section, and reviewed the manuscript. All authors hold themselves jointly to the content in the manuscript. Declaration of conflict of interest: The authors have no conflicts of interest to declare. Chizimuzo T. C. Okoli, PhD, MPH, MSN, RN. Sarret Seng, BA, BSN, RN. Janet K. Otachi, BSW, MA. Jacob T. Higgins, PhD, BSN, RN, CCRN-K. Jessica Lawrence, MSN, RN. Amanda Lykins, DNP, RN. Elizabeth Bryant, MSN, RN, CEN, CPEN, NE-BC. Accepted November 17 2019. © 2019 Australian College of Mental Health Nurses Inc. International Journal of Mental Health Nursing (2019) ,  doi: 10.1111/inm.12682