MSM 2001 Page 1of2 ":).':" IIJ: ~ Volume 1, 1995 Volume 2,1996 Volume 3, 1997 Volume 4,1998 Volume 5, 1999 Volume 6, 2000 Volume 7, 2001 Volume 8, 2002 ". ,.. 4P__ ~.I ...I .:r,'.I:.' sss MedSciManit,2002; 8(6): CR425-429 Atherosclerosis risk factors in children and adolescents with or without family history of premature coronary~arterY .disease Raya Kelishadi, Sarraf Zadegan, Gholam Naderi, Sedigueh Asgary, Nasrollah Bashardoust, Summary: Background: Although coronary artery disease (CAD) becomes symptomatic much later in life, the early identification and modification of risk factors may reduce its later incidence. Material/Methods: 100 subjects 2-18 years old, evenly divided by sex, were randomly selected from among children of patients suffering from premature myocardial infarction «55 years); the controls were 100age-'and sex-matched subjects without a similar family history. In the Pediatric Preventive Cardiology Clinic at the Isfahan Cardiovascular Research Center, the subjects completed a special questionnaire consisting of anthropometric data, blood pressure, skinfold thickness, rate of physical activity, and active or passive cigarette smoking. Fasting venous blood was analyzed for serum lipids, lipoproteins fibrinogen, and apolipoproteins A1 and B100. The data were analyzed with SPSS VMvin using the independent t-test, Kruskal-Wallis, chi-squared, and standard linear muftjple regression tests. Results: The data showed higher prevalence of some major and new risk factors in the experimental group than in the controls. The mean total cholesterol, LDL-C, TG, fibrinogen and Apo B100-were significantly higher in the experimental group, while the mean values of HDL-C and Apo A1 were significantly lower. The differences in tenns of Body Mass Index, percentage body fat, rate of regular physical activity, and active and passive smoking were not significant between groups. Conclusion: Major and new CAD risk factors should be identified imd modified as early as possible in children wfth high family risk by screening and health education at an early age. .- ."_. _~.. .. -0 ~ , ...keywords: premature coronary artery dis'ease · major & new risk factors · children Full-text PDF: http://www.MedSciM~n!t.com/pub/vo.-8/no_6/2498.pdf File size: 83 kB Comments r1~~h{fJ;r.;:\~p~;lI~.medscimonit;f~~~~~monitianic;:le _details.php?id=2498 01/08/1424' " .:~:." . / 11 I I . ; , . .