Research Article Restorative Prospective of Powdered Seeds Extract of Garcinia kola in Chrysichthys furcatus Induced with Glyphosate Formulation T. O. Ikpesu, 1 I. Tongo, 2 and A. Ariyo 1 1 Department of Biological Sciences, Federal University Otuoke, Nigeria 2 Department of Animal and Environmental Biology (AEB), University of Benin, Benin City, Nigeria Correspondence should be addressed to T. O. Ikpesu; tomohwofasa@yahoo.com Received 23 September 2013; Accepted 20 October 2013; Published 21 January 2014 Academic Editors: Y. Chen and Z. Qiusheng Copyright © 2014 T. O. Ikpesu et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Responses of Chrysichthys furcatus to glyphosate formulation and Garcinia kola seed extracts were investigated using the organization for Economic Cooperation and Development numbers 203 and 407 recommended toxicity bioassay. Te fsh were divided into fve groups and exposed to diferent treatments of glyphosate formulation and Garcinia kola seed extract, with the control serving as a reference. Water quality parameters and blood chemistry were estimated in the experimental and control fsh at the end of 28 days. Tere was no signifcant diference ( > 0.05) between fsh treated with glyphosate formulation alone and other treatments except for dissolved oxygen which was highly signifcant ( < 0.01) between fsh treated with glyphosate formulation alone and other treatments and the control. All the blood parameters were signifcantly ( < 0.05) afected by glyphosate formulation when compared with the control. Te changes observed in glyphosate formulation alone were reversible when G. kola seeds extract was added and was dose dependent. Te plant’s extract has shown to be a good remedy to pollutants, and formulations of the seed extract into tablets or capsules could serve as antidote to ameliorate the efects of pollutants. Tis fnding can reduce the risk of biomagnifcations of poisons along the food chain. 1. Introduction In the last few years there has been an exponential growth in the feld of herbal medicine and these drugs are gaining popu- larity both in developing and developed countries because of their natural origin and less side efects [1]. Herbal products cause few adverse efects but have benefcial pharmacological and therapeutic uses in a number of illnesses, including HIV where they have been examined for their capacity to reduce symptoms and improve quality of life [2]. Te literature review had shown that oral administration of an aqueous T. cordifolia root extract to alloxan diabetic rats caused a signif- icant reduction in blood glucose and brain lipids. Tough the aqueous extract at a dose of 400 mg/kg could elicit signifcant antihyperglycemic efect in diferent animal models, its efect was equivalent to only one unit/kg of insulin [3]. It is reported that the daily administration of either alcoholic or aqueous extract of T. cordifolia decreases the blood glucose level and increases glucose tolerance in rodents [4]. Also, oral administration of 2 and 8 g/kg of plant extract of fenugreek seeds produced dose dependent decrease in the blood glucose levels in both normal diabetic rats [5]. Te plant’s seed extract also improved glucose metabolism and normalized creatinine kinase activity in heart, skeletal muscle, and liver of diabetic rat [6]. Similarly, methanolic extract of Phyllanthus amarus was found to have potent antioxidant activity and reduced the blood sugar in alloxanized diabetic rats [7]. Garcinia kola (commonly called bitter kola) is an eco- nomic and highly valued tree available in large quantity in West Africa. Te fruit, seeds, nuts, and bark of the plant have been used extensively in African traditional medicine for the treatment of various diseases [8]. Te active constituent of the plant is dimeric favonoid molecules fused together by bifavonoid. Other constituents include xanthones and benzophenones [9]. Te dry powdered seeds contain 0.003% of favonoids while the crude extract contained 0.007% of Hindawi Publishing Corporation Chinese Journal of Biology Volume 2014, Article ID 854157, 8 pages http://dx.doi.org/10.1155/2014/854157