Annals of Clinical and Analytical Medicine 800 Annals of Clinical and Analytical Medicine Original Research Muhammad Imran Afab 1 , Madiha Ali 2 , Bushra Anam Ali 3 , Bilal Habib 4 , Inamul Haq 5 , Syed Imran Ali Shah 6 1 Department of Physiology, Independent Medical College, Faisalabad, Pakistan 2 Department of Anatomy, Independent Medical College, Faisalabad, Pakistan 3 Department of Pathology, Fazaia Medical College, Islamabad, Pakistan 4 Department of Physiology, Rai Medical College, Sargodha, Pakistan 5 Department of Physiology, University of Hafr Al-Batin, Hafar Al Batin, Saudi Arabia 6 Department of Biochemistry, University of Hafr Al-Batin, Hafar Al Batin, Saudi Arabia Subclinical hypothyroidism myocardial infarction Is subclinical hypothyroidism a risk factor for myocardial infarction? A comparative study of a cohort of young Pakistani men DOI: 10.4328/ACAM.20448 Received: 2020-12-23 Accepted: 2021-01-23 Published Online: 2021-02-05 Printed: 2021-07-01 Ann Clin Anal Med 2021;12(7):800-803 Corresponding Author: Syed Imran Ali Shah, Department of Biochemistry, University of Hafr Al-Batin, Hafar Al Batin, Saudi Arabia. E-mail: simranali@uhb.edu.sa / s.shah10@alumni.imperial.ac.uk P: +966534510690 Corresponding Author ORCID ID: https://orcid.org/0000-0002-0833-0771 Abstract Aim: Myocardial infarction (MI) is a major cause of death globally with a rising incidence at a younger age. Subclinical hypothyroidism (SCH) is an asymptom- atic condition with raised serum thyroid-stimulating hormone (TSH) and normal free thyroid hormones. SCH has been linked with MI previously, but local data are not available. The present study was done to determine the relation between SCH and MI in young men from the local population. Material and Methods: The cross-sectional study compared male patients with MI (n=75) with age-matched controls (n=75) for the presence of subclinical hypothyroidism and other clinical risk factors including blood pressure, waist circumference and fasting blood glucose (FBG). For the assessment of SCH, serum thyroid hormone profle was done, including TSH, free tri-iodothyronine (fT3) and free thyroxine (fT4) levels. Results: The incidence of SCH in MI patients and healthy control subjects were 12% and 5%, with the diference being statistically insignifcant (p=0.15.). No diferences were observed between the two groups in thyroid hormone profle and other clinical risk factors studied. Discussion: SCH does not appear to be associated with an increased risk of MI in local population of Pakistani men. Considering the study limitations, larger prospective trials are warranted to inform robust outcomes. Keywords Thyroid hormones; Subclinical hypothyroidism; Myocardial infarction; Cardiovascular diseases