Open Journal of Pathology, 2020, 10, 24-34 https://www.scirp.org/journal/ojpathology ISSN Online: 2164-6783 ISSN Print: 2164-6775 DOI: 10.4236/ojpathology.2020.101003 Jan. 3, 2020 24 Open Journal of Pathology The Histological Variants of Urothelial Carcinoma of the Bladder: It Is Affecting the Prognosis? Souhail Regragui 1,2 , Mohammed Alae Touzani 1,2* , Amine Slaoui 1,2 , Anas Mehedra 1,2 , Hafsa Elouazzani 3 , Tariq Karmouni 1,2 , Khalid El Khader 1,2 , Abdellatif Koutani 1,2 , Najat Mahassini 3 , Ahmed Ibn Attya Andaloussi 1,2 1 Faculty of Medicine and Pharmacy, Mohammed 5 University, Rabat, Morocco 2 “B” Urology Department, Ibn Sina Hospital, Rabat, Morocco 3 Pathology Department, Ibn Sina Hospital, Rabat, Morocco Abstract Urothelial carcinomas (UC) are likely to have particular morphological fea- tures that distinguish them from the typical form. These original aspects are called “histological variants of urothelial carcinoma”. They can constitute all or part of the tumor and concern mainly muscle invasive UC and high grade. Their frequency varies according to the type, but the knowledge of these va- riants is essential because of the diagnostic difficulties, and the implication of their presence on the prognosis. Keywords Urothelial Carcinoma, Variants, Prognosis 1. Introduction Urothelial carcinomas (UC) are likely to have particular morphological features that distinguish them from the typical form. These original aspects are called “histological variants of urothelial carcinoma”. They can constitute all or part of the tumor and concern mainly the muscle-invasive and high grade UC [1]. Their frequency is variable depending on the type (some variants are very exceptional). Knowing these variants is important because of the diagnostic difficulties, and the implication of their presence on prognosis [2]. Through this literature re- view, we present the different epidemiological, clinical, histological, prognostic and therapeutic aspects of each histological variant of urothelial carcinoma. How to cite this paper: Regragui, S., Tou- zani, M.A., Slaoui, A., Mehedra, A., Eloua- zzani, H., Karmouni, T., El Khader, K., Koutani, A., Mahassini, N. and Andaloussi, A.I.A. (2020) The Histological Variants of Urothelial Carcinoma of the Bladder: It Is Affecting the Prognosis? Open Journal of Pathology, 10, 24-34. https://doi.org/10.4236/ojpathology.2020.1 01003 Received: December 1, 2019 Accepted: December 30, 2019 Published: January 3, 2020 Copyright © 2020 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access