_____________________________________________________________________________________________________ *Corresponding author: E-mail: matthew.nwokike@gmail.com; Asian Journal of Research in Medical and Pharmaceutical Sciences 10(3): 32-40, 2021; Article no.AJRIMPS.73571 ISSN: 2457-0745 Hepatic Enzyme Effects of an Imperata cylindrica Extract M. O. Nwokike 1* , S. I. Ghasi 2 , E. C. Ogbuagu 2 , M. N. Ezenwaeze 3 and Akpotu E. Ajirioghene 4 1 Department of Pharmacology and Therapeutics, Ebonyi State University, Abakaliki, Nigeria. 2 Department of Pharmacology and Therapeutics, University of Nigeria, Enugu, Nigeria. 3 Department of Pharmacology and Therapeutics, Enugu State University College of Medicine, Enugu, Nigeria. 4 PAMO University of Medical Sciences, Port-Harcourt, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/AJRIMPS/2021/v10i330168 Editor(s): (1) Dr. S. Prabhu, Sri Venkateswara College of Engineering, India. Reviewers: (1) Mohd Adzim Khalili Bin Rohin, Universiti Sultan Zainal Abidin (UniSZA), Malaysia. (2) Pramod V. Pattar, Karnatak University, India. (3) K. A. Jeyanthi, Bharathidasan University, India. Complete Peer review History: https://www.sdiarticle4.com/review-history/73571 Received 14 July 2021 Accepted 22 September 2021 Published 07 October 2021 ABSTRACT This study was performed to investigate the effects of aqueous Imperata cylindrica root extract on hepatic enzyme levels of alloxan-induced diabetic male Wistar rats. Forty (48) male wistar rats were divided into six groups consisting of eight animals each. Diabetes mellitus was induced using intraperitoneal administration 150 mg/kg body weight of alloxan and treatment was carried out for a period of 28 days. The first group served as the normal control and received only feed and water ad libitum. In Group 2 were diabetic rats without treatment with extracts. Group 3: diabetic rats treated with 200 mg/kg aqueous Imperata cylindrica root extract. Group 4: diabetic rats treated with 400mg/kg aqueous Imperata cylindrica root extract. Group 5: diabetic rats treated with 600mg/kg ethanol extract of aqueous Imperata cylindrica root extract. While Group 6 was diabetic rats treated with 0.5mg/kg Glibenclamide. The liver enzymes alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase levels were significantly (p < 0.05) changed in rats Original Research Article