Article One-Year Follow-up Study on Minimally Invasive Treatment of Cariogenic or Non-cariogenic White Spot Lesions Raluca Lavinia Nit , u 1 , Ruxandra Sfeatcu 2, *, Ioana Giorgiana Pasca 1 , Lia Raluca Damian 1 , Ramona Cristina Dumitrescu 1 and Roxana Oancea 1 1 Discipline of Preventive, Community Dentistry and Oral Health, Faculty of Dental Medicine, “Victor Babes , ” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timis , oara, Romania; nituraluca30@gmail.com (R.L.N.); pascaioanagiorgiana@gmail.com (I.G.P.); damian.lia-raluca@umft.ro (L.R.D.); dumitrescu.ramona@umft.ro (R.C.D.); roancea@umft.ro (R.O.) 2 Department of Oral Health and Community Dentistry, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, 17-23 Calea Plevnei Street, 010221 Bucharest, Romania * Correspondence: ruxandra.sfeatcu@gmail.com Submitted: 11 April 2022; Accepted: 3 June 2022; Published: 30 July 2022 Abstract: (1) Background: The current practice in dental medicine aims to perform non-invasive treatments, which preserve as many hard tissues as possible. This trend is based on the final appearance, which should be as aesthetic and as close to natural teeth as possible. The use of Icon DMG can be considered revolutionary in the treatment of white spot lesions (WSLs) caused by various factors. (2) Methods: A diagnosis was established after clinical inspection, transillumination, or based on the patient’s medical history. Icon infiltration was followed according to the producer’s indications. Chromatic stability was assessed by two examinators with Vitapan 3D Master, and gum health improvement was assessed using the gingival index (GI). (3) Results: Ten dental units were observed for one year and showed chromatic stability. Gum health was improved. No side effects occurred. (4) Conclusions: An easy, non-invasive technique and painless treatment are the desired results from the use and implementation of resin in current practice. Following the infiltration protocol offers the desired aesthetic results. Keywords: white spot lesions (WSLs); resin infiltration; chromatic stability; gum health How to cite: Nit , u, R.L.; Sfeatcu, R.; Pasca, I.G.; Damian, L.R.; Dumitrescu, R.C.; Oancea, R. One-Year Follow-up Study on Minimally Invasive Treatment of Cariogenic or Non-cariogenic White Spot Lesions. Timisoara Med. 2022, 2022(2), 1; doi:10.35995/tmj20220201. Introduction White spot lesions (WSLs) are the clinical manifestation of an initial carious lesion, and they become visible due to the different refractive indexes of healthy and demineralized enamel. They are characterized by an opaque white area surrounded by healthy enamel. These are the first signs of teeth demineralization, and they occur on the smooth surfaces of the teeth. The enamel loses its translucency, which is directly connected to the degree of mineralization. Initially, pores are created between the enamel prisms, and as they develop, a porous structure is established [1]. For the proper clinical detection of WSLs, dental surfaces should be clean Timisoara Med. 2022, 2022(2), 1; doi:10.35995/tmj20220201 http://www.tmj.ro