D EVELOPMENT OF A QUORUM-S ENSING BASED BACTERIAL GMO FOR TARGETED T REATMENT OF B OVINE MASTITIS Abeg Dutta Department of Biological Sciences Indian Institute of Science Education and Research, Kolkata Mohanpur, West Bengal, India, 741246 ad19ms155@iiserkol.ac.in Sourin Chatterjee Department of Mathematics and Statistics Indian Institute of Science Education and Research, Kolkata Mohanpur, West Bengal, India, 741246 sc19ms170@iiserkol.ac.in Shreyas Pramod Borkar Department of Biological Sciences Indian Institute of Science Education and Research, Kolkata Mohanpur, West Bengal, India, 741246 sb18ms024@iiserkol.ac.in Shubhamay Das Department of Biological Sciences Indian Institute of Science Education and Research, Kolkata Mohanpur, West Bengal, India, 741246 sd18ms034@iiserkol.ac.in Udit Ghosh Department of Biological Sciences Indian Institute of Science Education and Research, Kolkata Mohanpur, West Bengal, India, 741246 ug19ms097@iiserkol.ac.in Adrija Adhikary Department of Biological Sciences Indian Institute of Science Education and Research, Kolkata Mohanpur, West Bengal, India, 741246 aa19ms124@iiserkol.ac.in August 7, 2023 ABSTRACT Bovine mastitis, a prevalent and costly disease affecting dairy cows, severely impacts milk production, quality, and cow health and poses significant challenges to the dairy industry worldwide. Traditional treatment strategies relying on antibiotics face concerns of antibiotic resistance and residual antibi- otic residues in dairy products. Therefore, there is an urgent need for innovative and sustainable . CC-BY-NC-ND 4.0 International license available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made The copyright holder for this preprint this version posted August 7, 2023. ; https://doi.org/10.1101/2023.08.07.552207 doi: bioRxiv preprint