This article is protected by copyright. All rights reserved Article Exosomes Secreted by Hypoxic Cardiosphere-derived Cells Enhance Tube Formation and Increase Pro-angiogenic miRNA † Running title: Hypoxic CDC-Exosomes Enhance angiogenesis in vitro Helia Namazi a,b , Elham Mohit a,c , Iman Namazi d , Sarah Rajabi e , Azam Samadian e , Ensiyeh Hajizadeh-Saffar e , Nasser Aghdami e* , Hossein Baharvand e,f* a Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. b Students Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. c Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. d School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. e Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. f Department of Developmental Biology, University of Science and Culture, Tehran, Iran. *Corresponding authors: Nasser Aghdami, aghdami@royaninstitute.org Or Hossein Baharvand, baharvand@royaninstitute.org † This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: [10.1002/jcb.26621] Additional Supporting Information may be found in the online version of this article. Received 23 October 2017; Accepted 12 December 2017 Journal of Cellular Biochemistry This article is protected by copyright. All rights reserved DOI 10.1002/jcb.26621