EFFICACY OF ANTIMICROBIAL PHOTODYNAMIC THERAPY IN DENTURE STOMATITIS: REPORT OF TWO CASES. RENAN BAERE DE SÁ OLIVEIRA, PEDRO ARTHUR DA SILVA RAMOS, PÂMELLA DE PINHO MOTOVANI, IRMA GONÇALVES REYS, BIANCA ALCÂNTARA DA SILVA, RENATA TUCCI, KARLA BIANCA FERNANDES DA COSTA FONTES. Denture stomatitis (DS) is a common lesion, and of its nu- merous etiological factors, the Candida species is important. Several strategies are adopted for its treatment; antimicrobial photody- namic therapy (aPDT) is a promising treatment that produces cytotoxic reactive oxygen species, inducing microbial killing. The aim was to report the efficacy of aPDT in 2 patients with DS as- sociated with Candida species. Measurement of clinical effectiveness and microbiologic evaluation were performed by using samples from the palatal mucosa and the prosthesis, inoculated in Sabouraud dextrose agar and CHROMagar Candida to determinate colony- forming units (CFU/mL). The patients were treated with 5 sessions of aPDT with 0.01% methylene blue and were irradiated with a laser at 660 nm (InGaAlP, 4J, 100mW; Photon lase III, DMC, São Paulo). The patients showed clinical remission of DS and signif- icant reduction of CFUs. Thus, aPDT may be a promising option for DS associated with Candida species. GORLIN-GOLTZ SYNDROME: A CASE REPORT OF A YOUNG PATIENT. JOABE DOS SANTOS PEREIRA, SÉRGIO HENRIQUE DE CARVALHO, DMITRY JOSÉ DE SANTANA SARMENTO, RAMON TARGINO FIRMINO, PEDRO ÉVERTON MARQUES GÓES, GUSTAVO GOMES AGRIPINO, SANDRA APARECIDA MARINHO. A 13-year-old boy presented with mandibular swelling. Extraoral examination revealed facial asymmetry, inflammatory lymphadenopathy, and polydactyly in both hands and feet. Pan- oramic radiography showed a well-delimited, radiolucent lesion on the left mandible. Sprengel deformity and mild thoracic defect were observed with conventional radiography. Skin showed no basal cell carcinoma. The clinical hypothesis included odonto- genic keratocyst and ameloblastoma. Incisional biopsy revealed a cyst lined with parakeratinized epithelium. The basal layer cells were columnar, palisaded, and hyperchromatic, features com- patible with odontogenic keratocyst. Gorlin-Goltz syndrome was considered according to 1 major and 3 minor criteria, odonto- genic keratocyst, Sprengel deformity, mild thorax deformity, and defective hands and feet, respectively. Cystic decompression was performed. The patient remains under follow-up care, with sig- nificant lesion decrease and bone neoformation. Enucleation will be conducted later. Diagnosis of Gorlin-Goltz syndrome is chal- lenging, given the varied forms of presentation. Careful investigation should be performed. ORAL MALIGNANT MELANOMA: A RARE CASE REPORT. ELIS ANDRADE DE LIMA ZUTIN, CELINA FAIG LIMA CARTA, BÁRBARA CORRÊA GERALDO, NOALA VICENSOTO MOREIRA MILHAN, ANA LIA ANBINDER, YASMIN RODARTE CARVALHO. A 76-year-old white man was referred for a nodular lesion in the right hard palate noticed about 8 months prior to presenta- tion. The lesion caused difficulty in fitting complete dentures, and an ulcerated surface caused intense bleeding after removal of the prosthesis. Intraoral examination revealed a black, 3 × 2 cm wide nodule exhibiting purple-colored bleeding areas, pedunculated and with well-defined borders and a lobulated surface. The differen- tial diagnosis included angiosarcoma and melanoma. Incisional biopsy and histopathologic analysis showed a malignant neo- plasm with polyhedral and epithelioid cells, with eccentric nuclei and brown pigmentation in the cytoplasm. These cells finally changed to multinucleated forms and invaded the connective tissue. With a final diagnosis of melanoma, a surgical procedure was sug- gested. Oral melanomas are a rare entity in the oral mucosa, with poor prognosis as a result of delay in diagnosis, especially in older people. BONE TRABECULAE ALTERATIONS IN THE MANDIBLE OF A PATIENT TREATED WITH TNF-Α INHIBITORS DUE TO PSORIATIC ARTHRITIS. SANDRA CARVALHO SUZUKI, ROGERIO ZAMBONATO FREITAS, SERGIO SARGENTI NETO, BERNAR MONTEIRO BENITES, MARCO AURELIO PETRONI MONTEZUMA, FELIPE PAIVA FONSECA, EDUARDO RODRIGUES FREGNANI. Psoriatic arthritis (PsA) is a chronic inflammatory joint disease closely associated with psoriasis. A significant advance in the man- agement of this condition was achieved with therapeutic schemes by using tumor necrosis factor (TNF)-α inhibitors. Bone altera- tions, such as osteomyelitis and osteonecrosis associated with the use of a wide variety of monoclonal drugs, are known to affect the maxilla and especially the mandible. This report describes the case of a 45-year-old man with PsA treated with TNF-α inhibi- tors, including adalimumab, and demonstrated alterations in the mandibular bone trabeculae. As the patient’s PsA was deemed re- fractory to treatment and control, the monoclonal antibody anti- interleukin- 17A, secukinumab (Cosentyx), was used. Psoriasis and PsA were controlled, but mandibular osteosclerosis worsened. A RARE CASE OF CHERUBISM IN TWINS: CLINICAL IMAGING DIAGNOSIS. JÉSSICA LOURDES DE AGUIAR GONÇALVES, TIAGO NOVAES PINHEIRO, GIMOL BENCHIMOL DE RESENDE PRESTES, KEULY SOUSA SOARES, RODRIGO FERREIRA DE OLIVEIRA, ELIANE DE OLIVEIRA ARANHA RIBEIRO. Cherubism is a rare autosomal dominant syndrome charac- terized by abnormal bone tissue in the lower part of the face and tends to be self-limiting. We report a case of cherubism diag- nosed in 4-year-old twins. Clinical examination revealed bilateral swelling of the jaws, rigid, nonfloating, with no color changes. Ad- ditionally, the deciduous dentition revealed no caries. Computed tomography of the jaws showed osteolytic, multilocular areas in the body and ramus of the mandible, and in the posterior of the maxilla, with cortical involvement. The lesions were quiescent and asymptomatic. The cases were followed up with periodic exami- nations for more than 18 months, and no significant changes were observed in both patients. Awareness of the condition and profes- sional guidance is important for early detection of any complication that may arise. REPORT OF FOUR CASES OF LOCALIZED JUVENILE SPONGIOTIC GINGIVAL HYPERPLASIA: A LONG-TERM FOLLOW-UP STUDY. DIEGO TETZNER FERNANDES, JOHN M. WRIGHT, SILVIA MARIA PAPAROTTO LOPES, ALAN ROGER SANTOS-SILVA, PABLOAGUSTIN VARGAS, MÁRCIO AJUDARTE LOPES. OOOO ABSTRACTS Volume 126, Number 3 Abstracts e67