Cronicon OPEN ACCESS EC DENTAL SCIENCE EC DENTAL SCIENCE Research Article Regenerative Endodontic Treatment in Clinical Practice: A Systematic Review Hatem Faisal Bajnaid 1 *, Hussain Zaki Alabdulwahhab 2 , Abdulhadi Mohammed Albandar 3 , Khulud Nasser Alhmamey 4 , Rahaf Abdullah Manzalawi 4 , Nada Mohammed Fallatah 5 , Renad Khalid Alamoudi 6 , Reem Mohammed Alharbi 6 , Asuf Naif Alabdali 7 , Abdulmalik Ahmed Alburayk 8 and Maryam Nabeel Nasser 6 1 Department of Endodontics, King Fahad Hospital, Jeddah, Saudi Arabia 2 Primary Health Care, Ministry of Health, Ras Tanura, Saudi Arabia 3 Primary Health Care, Ministry of Health, Hail, Saudi Arabia 4 College of Dentistry, Batterjee Medical College, Jeddah, Saudi Arabia 5 College of Dentistry, Alfarabi Colleges, Jeddah, Saudi Arabia 6 College of Dentistry, Ibn Sina National College, Jeddah, Saudi Arabia 7 General Dentist, FMC, Jeddah, Saudi Arabia 8 College of Dentistry, Alfarabi Colleges, Riyadh, Saudi Arabia Citation: Hatem Faisal Bajnaid., et al. “Regenerative Endodontic Treatment in Clinical Practice: A Systematic Review”. EC Dental Science 19.10 (2020): 95-106. *Corresponding Author: Hatem Faisal Bajnaid, Department of Endodontics, King Fahad Hospital, Jeddah, Saudi Arabia. Received: August 12, 2020; Published: September 24, 2020 Abstract Recently, regenerative endodontic treatment (RET) has been recognized as a ‘paradigm shift’ regarding the management of im- mature teeth associated with pulp necrosis. Various reports have suggested the use of RET as a first-line therapeutic option when dealing with immature teeth, particularly when the roots are not yet fully developed. For that, a systematic electronic database search was conducted for relevant studies published from inception and till 24 th June 2020 in seven databases. Several position statements and clinical recommendations regarding the use of RET in clinical practice have been released by the European Society of Endodon- tology (ESE) and the American Association of Endodontists (AAS). Such treatment modalities depend upon the tissue engineering concept components, including stem cells, scaffolds, and signaling molecules. In clinical practice, this treatment approach involves the process of disinfection and commonly the introduction of a blood clot into the root canal space. There are three main therapeutic goals of RET. The first goal is the resolution of associated clinical signs and symptoms. The second goal is to establish further root maturation. The final goal is the restoration of neurogenesis. Up till this point, RET has been unable to reach a proven result regarding the real regeneration of pulp tissue and dentine space. From a histological aspect, healing is achieved with repair from tissues that are originated mainly from the periodontal and osseous tissues, including bone-like tissues and cementum, rather than odontoblasts and pulp tissues. We have conducted the current literature review to provide an overview of the clinical and biological aspects of regenerative endodontic treatment. Keywords: Regenerative; Endodontic; Treatment; Pulp: RET Introduction The main aim of pulp treatment is to maintain the structure of the tooth intact in order to preserve optimal functionality. Another purpose of pulp treatment is to maintain the vitality of the teeth that are damaged secondary to dental caries or trauma. Particularly, in