Journal of Research in Medical and Dental Sciences Volume 5, Issue 5, Page No: 13-18 Copyright CC BY-NC-ND 4.0 Available Online at: www.jrmds.in eISSN No. 2347-2367: pISSN No. 2347-2545 Journal of Research in Medical and Dental Science | Vol. 5 | Issue 5 | November 2017 13 Correlation Duration of Oral Steroids Drug Administration by Intraocular Pressure in Patients with Systemic Lupus Erythematosus (SLE) in Dr. Mohammad Hoesin General Hospital Palembang Syarif Satya Graha 1 , Fidalia 1 , Prima Mayasari 1 , Nova Kurniati 2 , Irsan Saleh 3 * 1 Ophthalmology Departement, Moh.Hoesin General Hospital, Palembang, Indonesia 2 Internal Medicine Department, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia 3 Department of Pharmacology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia DOI: 10.24896/jrmds.2017553 ABSTRACT Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease and multisystem organ involvement. SLE patients given treatment are manifold, one of which is with steroids. Long time drug administration depends on the clinical condition of the patient. Oral steroids may cause an increase in intraocular pressure, depending on the type of steroid that is administered, the route of administration and duration of taking the medication. To determine the correlation length of oral steroid drug administration by intraocular pressure in patients with SLE in dr. Mohammad Hoesin general hospital (RSMH) Palembang. This study was an observational study exploratory. Intra-ocular pressure examination uses Goldmann Tonometry Aplanation in patients with SLE who use oral steroid medication (methylprednisolone) in RSMH Palembang. Data were analyzed with correlation. Hypothesis test results correlation between duration of oral steroid drug (metylprednisolone) with intraocular pressure in patients with SLE using Spearman Correlations test obtained r = 0.054 and p = 0.637. There was no significant correlation between the duration of oral steroid medication (methylprednisolone) with intra-ocular pressure in patients with SLE. But looks very weak correlation strength. Key words: Intraocular pressure, metylprednisolone, Steroid induced glaucoma, Systemic Lupus Erythematosus (SLE). HOW TO CITE THIS ARTICLE: Syarif Satya Graha, Fidalia, Prima Mayasari, Nova Kurniati,Irsan Saleh, Correlation Duration of Oral Steroids Drug Administration by Intraocular Pressure in Patients with Systemic Lupus Erythematosus (SLE) in Dr. Mohammad Hoesin General Hospital Palembang, J Res Med Dent Sci, 2017, 5 (5): 13-18, DOI: 10.24896/jrmds.2017553 Corresponding author: Irsan Saleh e-mailirsan.saleh.hasani@gmail.com Received: 28/08/2017 Accepted: 22/09/2017 INTRODUCTION Intraocular pressure (IOP) is a biological entity that shows daily fluctuations. IOP is required for normal vision which ensures the clearness of eye media and the constant distance between cornea with lens and lens with retina [1-5] Corticosteroids can cause glaucoma by elevating IOP with open angle mechanisms. The mechanism is associated with a double effect on trabecular meshwork, another mechanism leading to cytoskeletal changes that may inhibit pinocytosis from the aqueous humor. Corticosteroids also lead to a decrease in prostaglandin synthesis that regulates excretion of aqueous humor that resulting in increased IOP causing pressure on the optic nerve and causing visual disturbance and visual nerve damage [6-10]. Increasing of IOP incidence caused by systemic steroid consumption is not known for sure because most of these sufferers do not do IOP examination. These sufferers may be found during routine eye examinations [6, 7]. One of the systemic diseases that commonly use corticosteroid therapy in its treatment is Systemic Lupus Erythematosus (SLE) disease which is a chronic autoimmune disease and has multisystem organ involvement. Eyes are not the primary target of SLE mediated by immune disorders, but can affect significant ocular morbidity. Ocular disorders due to side effects of steroid use are often overlooked by health personnel so that