Lathika A Nayak, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 78-87 | Review *Corresponding Author: Lathika A. Nayak Address: PharmD Intern, Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore,Karnataka-574143 Email     : nayaklathika57@gmail.com Relevant conflicts of interest/financial disclosures: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. INTERNATIONAL JOURNAL IN PHARMACEUTICAL SCIENCES 78 | Page One of the leading causes of maternal morbidity and mortality during pregnancy is pregnancy-induced hypertension. Hypertension that persists complicates between 1% and 5% of pregnancies. A combination of α- and β-adrenoceptor antagonist, labetalol is currently used to treat hypertension. It functions as a competitive antagonist of postsynaptic α-adrenoceptors and a nonselective competitive antagonist at β- adrenoceptors. Comparing it to other β blockers, it can preserve uteroplacental circulation more effectively. Additionally, a comparison was done between labetalol and other medications used for comparable purposes. INTERNATIONAL JOURNAL IN PHARMACEUTICAL SCIENCES Journal Homepage: https://www.ijpsjournal.com Review Article Labetalol For The Treatment Of Pregnancy Induced Hypertension: A Brief Review A. R. Shabaraya 1 , Lathika A. Nayak* 2 1 Professor and Head, Department Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka 574143 2 PharmD Intern, Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka 574143 ARTICLE INFO ABSTRACT Received: 28 Nov 2023 Accepted: 01 Dec 2023 Published: 05 Dec 2023 Keywords: Pregnancy induced hypertension, postsynaptic, labetalol, antagonist, combination DOI: 10.5281/zenodo.10259558 INTRODUCTION In the developed world, hypertensive problems during pregnancy are the second largest cause for immediate maternal death. The most frequent medical issue that arises during pregnancy is hypertension. In order to avoid issues for the mother and the unborn child, it is crucial to manage hypertension during pregnancy as it can be a serious condition.1 A beta-blocker called labetalol lowers blood pressure and heart rate. Because it is widely regarded as safe during pregnancy and has been demonstrated to be effective in decreasing blood pressure, pregnant women frequently use it. To guarantee the best outcome for the mother and the unborn child. As a β-blocker, labetalol works by altering how certain body organs, like the heart, react to nerve impulses. As a result, blood pressure drops and heart rate lowers. The heart receives more blood and oxygen when blood pressure falls.2 It functions as a competitive antagonist of postsynaptic α-adrenoceptors and a nonselective