American Journal of Nursing Research, 2019, Vol. 7, No. 4, 550-560 Available online at http://pubs.sciepub.com/ajnr/7/4/17 Published by Science and Education Publishing DOI:10.12691/ajnr-7-4-17 Fatigue and Self-management among Multiple Sclerosis Patients Afnan Seraj Jamal Shawli 1,* , Iman Abdallah Mohammed Abdulmutalib 2 , Elham Abduallah Al Nagshabandi 2 1 Master Candidate of Medical-Surgical Nursing, King Abdulaziz University, Jeddah, KSA 2 Medical-Surgical Nursing Department, Nursing Faculty, Ain Shams University, Cairo, Egypt *Corresponding author: Afnansh-sh@hotmail.com Received March 10, 2019, 2019; Revised April 22, 2019; Accepted May 27, 2019 Abstract Fatigue is considered as the most revealed symptoms in multiple sclerosis patients, reported by 88% of patients and has significant impact on all stages of life such as altering in daily living activity or psychosocial/mental functions. The pathogenesis of fatigue remain poorly understood and how its impact on self-management. The aim of study was to assess fatigue and self management among multiple sclerosis patients. A quantitative descriptive correlational design was used in this study. The study was conducted at both King Abdulaziz University Hospital and King Fahad Armed Forces Hospitals in Jeddah City from January till March 2018, data collected from outpatients’ clinic and Inpatients’ medical-wards. A convenience sample of 50 Multiple Sclerosis patients. Data was collected through the main one tool, it consists of three parts; Part I, Socio-demographic and clinical data constructed by the researchers. Part П, Modified Fatigue Impact scale; to assess the Impact of fatigue on physical, cognitive, and psychosocial functioning in patient with Multiple Sclerosis.. Part ПІ, Multiple Sclerosis Self Management Scale Revised; to provide a multidimensional and psychometrically assessment of self-management knowledge and behavior among Multiple Sclerosis patients. The study results showed there was a statistically significant negative correlations between fatigue subscales and overall self-management among Multiple Sclerosis patients with p-value (.019). Also, there was a statistically significant negative correlations between self-management factor scales and overall fatigue among Multiple Sclerosis patients with p-value (.019). It was concluded that there was a negative correlations between overall fatigue and overall self-management among Multiple Sclerosis patients, whenever fatigue severity increases, self-management decreases. It was a recommendation to encourage governmental policy and other decision makers in the Saudi community to develop periodically structure health education training program regarding self-management in MS and provide appropriate environments or facilities to conduct such programs, where nurses play a key role through health education and cooperate with other health care system. Keywords: fatigue, multiple sclerosis, self-management Cite This Article: Afnan Seraj Jamal Shawli, Iman Abdallah Mohammed Abdulmutalib, and Elham Abduallah Al Nagshabandi, “Fatigue and Self-management among Multiple Sclerosis Patients.” American Journal of Nursing Research, vol. 7, no. 4 (2019): 550-560. doi: 10.12691/ajnr-7-4-17. 1. Introduction The progressive nature of Multiple Sclerosis (MS), variability of its symptoms lead to emotional or social changes and create a complex combination in which challenge healthcare professionals [1]. The direct medical costs of MS in the United State are estimated of 10$ billion per year, and the indirect costs remains higher costs through reduced employment or unemployment, need for assistive equipment, paid personal care and productivity loss on later MS progression [2]. According to [3] who reported that in Saud Arabia, each neurology clinic visit for each MS patients coast around 820 Saudi Riyal from the stage of diagnosis to stage of receive require care in the last six years at King Faisal Specialist Hospital & Research Center. Multiple Sclerosis chronic nature and its long term complications, emerge need of multidisciplinary services. In which nurses have the key role in interacting with patients and their families throughout empower patients in selecting appropriate healthy behaviors management [4]. Multiple Sclerosis is a progressive, inflammatory, neurode-generative demyelinating disease of the centeral nervous system (CNS) characterized by chronic inflammation, demyelination, and scarring (plaques) of the nerve fibers in central nervous system mainly affecting white matter with the incidence rate in women is twice than of men [5]. The main cause of MS clinical symptoms are these plaques which deter transmission of regular electrical impulses, lead to one or more of the following symptoms;