_____________________________________________________________________________________________________ *Corresponding author: E-mail: Star920@yahoo.com; Journal of Pharmaceutical Research International 33(54A): 307-312, 2021; Article no.JPRI.76895 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Impact of Alternative Routes and Timing of Dopamine and Mannitol Administrations to Reduce Negative Properties of Extended Cardiopulmonary Bypass on Renal Function in Coronary Artery Operations Iqra Ejaz a , Salwa Naeem b , Mian Seher Munir c , Muhammad Usman d , Sohail Zafar e and Faiza Hanif f* a PMC #: 89543-P, Allama Iqbal Memorial Hospital, Sialkot, Pakistan. b PMC #: 106693-P, Allied Hospital, FMU, Faisalabad, Pakistan. c PMC #: 94079-P, DHQ Teaching Hospital, Gujranwala, Pakistan. d PMDC #: 87319-P, Pakistan Institute of Medical Science Hospital Islamabad, Pakistan. e PMDC #: 60525-P, Combined Military Hospital, Quetta, Pakistan. f PMC #: 59534-P, PGR, Mphill Anatomy, PGMI, Lahore, Pakistan. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i54A33751 Editor(s): (1) Dr. S. Srinivasa Rao, V. R. Siddhartha Engineering College, India. Reviewers: (1) Ofir Koren, Smidt Heart Institute, Cedars-Sinai Medical Center, USA. (2) Mehmet Sarier, Istinye University, Turkey. Complete Peer review History, details of the editor(s), Reviewers and additional Reviewers are available here: https://www.sdiarticle5.com/review-history/76895 Received 18 September 2021 Accepted 28 November 2021 Published 10 December 2021 ABSTRACT Objectives: To analyze impact of alternative routes and timing of dopamine and mannitol administrations to reduce negative properties of extended cardiopulmonary bypass on renal function in coronary artery operations. Methods: Set I (n: 26 individual): Mannitol (1 g/kg) has been introduced to the CPB priming solution. Set II (n: 25 patients): Even during interval among anesthetic induction and operation, 3 g/kg/min of IV dopamine was delivered. Group III (n = 25 patients): 2 g/kg/min IV dopamine was provided among anesthesia initiation and operation conclusion, and 1 g/kg mannitol were added to Original Research Article