J. Appl. Environ. Biol. Sci., 3(7)6-9, 2013 © 2013, TextRoad Publication ISSN: 2090-4215 Journal of Applied Environmental and Biological Sciences www.textroad.com *Corresponding Author: Bahram Abdi (Ph.D.). Department of Physiology, Faculty of Biology, Baku State University, Azerbaijan. E-mail: Abdi.bahram2@yahoo.com Effects of Interoceptive Stimulation on Glycemic Reactions in Brain Different Functional States under Physical Loading Parvin Zulfugarova, Ali Aliyev, Fatemeh Aliyev and Bahram Abdi Department of Physiology, Faculty of Biology, Baku State University, Azerbaijan ABSTRACT As it issues from the conducted studies, in intact animals and in the animals of different ages kept in light regime after epiphys-ectomy glucose levels in the blood at 8.00-9.00 A.M. is minimal, in the afternoon, at 1.00-2.00 P.M. it up-regulates significantly, while in the evening, at 6.00-8.00 it gets down. In the animals kept under dark- ness regime the blood glucose levels run down. It is revealed that after subjecting to short-term physical loading in the 30, 90, 180-day-old animals in the morning, afternoon and evening time of circadian rhythm up-regulation of glycemic reactions is observed, whereas long-term physical loading results in down-regulation of this index values. After keeping the animals under 7-day light and darkness regimes and subjecting them to olfactory- ectomy and interoceptive stimulation down regulation of the blood glucose level is observed, while after 14 days recovery in hypothalamo-hypophysal and other analysators systems takes place. On the grounds of the obtained data one can come to a conclusion that epiphysal hormone melatonin might be used for therapeutics purposes in the clinical practice. KEYWORDS: Epiphys, Light, Darkness, Glycemic, Olfactory Nerve 1. INTRODUCTION As it is known from the literature, information about external milieu and its changes comes to the brain through sensor apparatus engaged into regulation of functional and metabolic reactions, and sensor nerves and thereafter gets down to motor and secretor organs. Studies of dynamic interrelations between motor activity, tissue metabolism being under direct and indirect influences of rhythmic and sequential movements, homeostasis of internal milieu and distinct functional states from fundamental and applicable standpoints compose one of the most prominent physiological problems. Studies of changes in the form of blood glycemia in the organisms subjected to intensive physical loading always challenge tremendous interest. Particularly, physical loadings of different intensities in short time induce different magnitude changes of turnover indexes of blood carbohydrates, proteins and lipids [1, 2, 3, 4, 5, 6, 7 and 8]. Extra-sensor apparatus, mighty sensor pathways and centers of the brain have broad mutual relations with such important viscero-sensory and neuroendocrine structures as hypothalamus and hypophysis and effects- dependent endocrine activity of epiphysis which in relation to light (daytime) and dark (night) phases in rhythmic way tunes up on active and passive status of secretor activity in the form of hormone (melatonin) production. Circadian rhythm underlies fluctuations of glucose levels in healthy humans as well as in most mammals; on the other hand, in light-subjected mice glucose level in the blood increases, while in darkness its level goes down [9, 10, 11, 12]. At the same time these changes in epiphysis functioning in response to light and darkness conditions are reflected in dynamics of all listed above processes and functions and engage them into general chronometric and biorhythmic regulatory mechanisms of the organism fixed in phylogenesis and ontogenesis [13, 14]. 2. MATERIAL AND METHODS For this purpose we used effects of physical loading in our experiments. In order to subject the experimental animals to physical loading in experimental conditions most of researchers utilize rotating mechanical device having form of a drum with empty cavity. Velocity of drum rotation lies within limits of 40-50 rpm and rabbits this way are subjected both to forced running and vibration effects for 5 and 20 min. The glucose level in the blood was measured with application of express method in glycometer (production of Bayer-Holding Company, USA and Canada). The experiments are carried out in the following series. 6