IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 16, Issue 4 Ver. VI (April. 2017), PP 13-18 www.iosrjournals.org DOI: 10.9790/0853-1604061318 www.iosrjournals.org 13 | Page Comparison and Correlation of Cytology, Colposcopy and Histopathology of Premalignant Lesions of Cervix In Rural Women of Barabanki District Dr.Shashwat Vidyadhar 1* , Dr.Aarti B.Bhattacharya 2 , Dr.Sangita Bohara 3 , Dr.A.D. Dwivedi 4 , Dr.Anjana Agarwal 5 , Dr.Deepti Gangwar 6 1 Post-Graduate Resident, Department of Pathology, Hind Institute of Medical Sciences, Barabanki, U.P. 2 Professor, Department of Pathology, Hind Institute of Medical Sciences, Barabanki, U.P. 3 Assistant Professor, Department of Pathology, Hind Institute of Medical Sciences, Barabanki, U.P. 4 Professor & Head, Department of Obstetrics & Gynaecology, Hind Institute of Medical Sciences, Barabanki, U.P. 5 Professor, Department of Obstetrics & Gynaecology, Hind Institute of Medical Sciences, Barabanki, U.P. 6 Post-Graduate Resident, Department of Pathology, Hind Institute of Medical Sciences, Barabanki, U.P. Abstract Aims and Objective: (1)To record the colposcopic and cytological findings of the cases and to compare it with each other in detecting premalignant lesions of cervix taking histopathology as gold standard.(2)To correlate the findings of cytology and colposcopy with histopathology in detecting premalignant lesions of cervix. Materials and Methods: This was a hospital based cross-sectional study conducted at HIMS,Barabanki.The study period was of one year.The study included pap smear samples,colposcopy reports and colposcopy guided cervical biopsy samples of 208 sexually active rural female patients of reproductive age group. Results: Majority of the women were between 31-40 years(59.6%).On PAP smear,ASC-US was found in 5.8% of women,ASC-H in 1.4% of women,LSIL in 6.7% of women and HSIL in 6.2% of women.On colposcopy,LSIL was seen in 26.4% of women and HSIL in 17.8% of women.On histopathological examination,CIN I was seen in 16.8% of women followed by CIN II(8.2%)and CIN III(5.8%).Sensitivity and specificity of PAP smear was 29.7% and 94.4%.Sensitivity and specificity of colposcopy was 85.9% and 74.3%. Conclusion: Pap smear had a poor sensitivity compared to colposcopy but a better specificity than colposcopy.Hence,it may be better to utilise both tests in screening of premalignant lesions of cervix as they complement each other. Keywords: Premalignant Lesions of Cervix,Cytology,Colposcopy, Histopathology. I. Introduction Cancer cervix is the second most common cancer in women after carcinoma breast in the world, while it is the leading cancer in women in the developing countries including India. 1 More than 80% patients present in a fairly advanced stage. 2 According to the GLOBOCAN statistics, the estimated incidence of cervical cancer in the world is 528000 per year with 266000 annual deaths attributed to cervical cancer (approximately 50%). 3 India alone contributes to 23% of the total global cases annually. With an annual 67000 deaths, cervical cancer remains one of the major causes of cancer related mortality in India. 4 Cervical intraepithelial neoplasia (CIN) is a premalignant condition of the uterine cervix.Detected in pre-malignant stages,cervical cancer is preventable and curable,so detection of premalignant lesions is very important. II. Aims And Objective The present study was conducted with aims and objectives to (1) to record the colposcopic and cytological findings of the cases and to compare it with each other in detecting premalignant lesions of cervix taking histopathology as gold standard; (2) to correlate the findings of cytology and colposcopy with histopathology in detecting premalignant lesions of cervix. III. Materials And Methods This was a hospital based cross-sectional study. The study was conducted in the Department of Pathology and Department of Obstetrics & Gynaecology, Hind Institute of Medical Sciences, Safedabad, Barabanki, U.P. The study was performed after permission from Institutional Ethics Committee. The study period was of one year(2015-2016). The study included pap smear samples, colposcopy reports and colposcopy guided cervical biopsy samples of 208 sexually active rural female patients of reproductive age group, in and