Indian Journal of Clinical Anaesthesia 2023;10(2):150–157 Content available at: https://www.ipinnovative.com/open-access-journals Indian Journal of Clinical Anaesthesia Journal homepage: www.ijca.in Original Research Article Comparative evaluation of propofol, thiopentone and etomidate on induction time, intubation response and recovery time during laparoscopic surgery under general Anaesthesia Sooshrut Thakur 1 , Aarti Sharma 2 , Ramesh Kumar 2, *, Jyoti Pathania 2 , Garima Thakur 3 1 Dept. of Anaesthesia, Civil Hospital, Kangra, Himachal Pradesh, India 2 Indira Gandhi Medical College, Shimla, Himachal Pradesh, India 3 Dr. Rajendra Prasad Government Medical College, Tanda, Himachal Pradesh, India ARTICLE INFO Article history: Received 20-01-2023 Accepted 03-05-2023 Available online 05-06-2023 Keywords: Hypotension General surgery Propofol Etomidate Barbiturates Hemodynamics ABSTRACT Background: Optimal choice of inducing agent can partially modify the post induction hypotension, having a reported incidence of 9-40% in various studies. So, we compared the induction and recovery profile of the routinely available induction agents. Materials and Methods: This prospective randomized, comparative study was carried out on 120, ASA 1 and II patients undergoing routine laparoscopic cholecystectomy. Patient received either thiopentone 5 mg/kg, propofol 2.0 mg/kg or 0.3mg/kg injection etomidate at induction in group T, P and E respectively. The time taken from the administration of inducing agent to loss of eyelash reflex was noted. Heart rate, systolic, diastolic and mean arterial pressure, SpO2 was recorded at 1, 2, 3, 4, 5, 6 minutes and every five minutes after intubation. Steward score and the vitals were noted every 5 minutes after extubation till 30 minutes. It was noted that how long it took to get a Steward score of 6. Results: The mean induction time (sec) was 49.85 ±2.54 in group T, 43.45 ±2.66 in group P and 52.675 ±2.11 in group E. (p<0.0001). The increase in mean heart rate from baseline upon induction and intubation was (10%, 31% in group T), (3%, 23% in group E) and (-7%, 16% in group P) (p<0.0001). Post induction decrease in systolic, diastolic and mean blood pressures observed in group T was (-9%, -4.5%, -6%), (-12.8%, -9.8%, -11%), in group P and (-4.6%, -1.7%, -2.9%) in group E. (p<0.0001). Post intubation increase in systolic, diastolic and mean blood pressures was (21.76%, 18%, 19.7%) in group T, (16%, 8.1%, 11.7%) in group E and (9.6%, 0%, 4%) in group P. Mean recovery time in min was 5.87 ±0.23 min with propofol, 6.97 ±0.28 with etomidate and 8.96 ±0.28 with thiopentone. (p<0.0001). Conclusion: Amongst the three agents, we recommend propofol as preferred agent for induction due to faster induction, better attenuation of intubation response, faster recovery and stable hemodynamic parameters. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact: reprint@ipinnovative.com 1. Introduction Discovery of thiopentone in 1934 heralded the changes in safe intravenous anesthesia practice followed by discovery of etomidate and propofol. 1,2 Intravenous anaesthetics are * Corresponding author. E-mail address: sooshrut@gmail.com (R. Kumar). used to induce general anaesthesia in patients, in addition they are used for sedation in the intensive care unit (ICU) and the management of status epilepticus. 2 The quest for identification of an ideal intravenous anaesthetic persist due to the cardiorespiratory depression that all of these agents produce, despite their admirable https://doi.org/10.18231/j.ijca.2023.030 2394-4781/© 2023 Innovative Publication, All rights reserved. 150