Progressive Loss of Brain Volume in Children with Sickle Cell Anemia and Silent Cerebral Infarct: A Report from the Silent Cerebral Infarct Transfusion (SIT) Trial Deepika S. Darbari 1,2 , Odianosen Eigbire-Molen 3 , Maria R. Ponisio 4 , Mikhail V. Milchenko 4 , Mark J. Rodeghier 5 , James F. Casella 6 , Robert C. McKinstry 7 , and Michael R. DeBaun 8 1 Division of Hematology, Children's National Medical Center, Washington, DC; 2 The George Washington University School of Medicine and Health Sciences, Washington, DC; 3 Division of Pathology, St. Louis University, St. Louis, MO; 4 Department of Radiology, Washington University School of Medicine, St. Louis, MO; 5 Rodeghier Consultants, Chicago, IL; 6 Department of Pediatrics, Division of Hematology, Johns Hopkins School of Medicine, Baltimore, MD; 7 Pediatric Radiology and Neuroradiology Sections, Washington University School of Medicine, St. Louis, MO; 8 Department of Pediatrics, Vanderbilt-Meharry Center of Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN Address correspondences to: Michael R. DeBaun, MD, MPH, Vanderbilt-Meharry-Matthew Walker Center of Excellence in Sickle Cell Disease, Department of Pediatrics, Vanderbilt University School of Medicine, 2200 Children’s Way, 11206 DOT, Nashville, TN 37232-9000, USA, Phone: 615-875-3055, m.debaun@vumc.org Accepted Article This article is protected by copyright. All rights reserved. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/ajh.25297