Accepted Manuscript Development of novel pyridazinone-based adenosine receptor ligands Daniela Catarzi, Flavia Varano, Matteo Falsini, Katia Varani, Fabrizio Vincenzi, Silvia Pasquini, Diego Dal Ben, Vittoria Colotta PII: S0960-894X(18)30291-9 DOI: https://doi.org/10.1016/j.bmcl.2018.03.086 Reference: BMCL 25740 To appear in: Bioorganic & Medicinal Chemistry Letters Received Date: 15 February 2018 Revised Date: 28 March 2018 Accepted Date: 29 March 2018 Please cite this article as: Catarzi, D., Varano, F., Falsini, M., Varani, K., Vincenzi, F., Pasquini, S., Dal Ben, D., Colotta, V., Development of novel pyridazinone-based adenosine receptor ligands, Bioorganic & Medicinal Chemistry Letters (2018), doi: https://doi.org/10.1016/j.bmcl.2018.03.086 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.