Letter to the Editor Response to: Comment on (Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer’s Type Dementia) Mehmet Bulut, 1 Aylin Yaman, 2 Muhammet Kazim Erol, 1 Fatma KurtuluG, 2 Devrim Toslak, 1 Berna DoLan, 1 Deniz Turgut Çoban, 1 and Ebru Kaya BaGar 3 1 Antalya Training and Research Hospital, Ophthalmology Department, 07050 Antalya, Turkey 2 Antalya Training and Research Hospital, Neurology Department, 07050 Antalya, Turkey 3 Department of Animal Science Biometry and Genetics Unit, Faculty of Agriculture, Akdeniz University, 07070 Antalya, Turkey Correspondence should be addressed to Mehmet Bulut; bulutme73@yahoo.com Received 28 June 2016; Accepted 9 August 2016 Academic Editor: Jes´ us Pintor Copyright © 2016 Mehmet Bulut et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In our study, we found out that choroidal thickness (CT) decreased in the eyes of patients with both Alzheimer’s type dementia (ATD) and mild cognitive impairment (MCI) com- pared to the healthy control group. Terefore, we suggested that CT value could be used as a new biomarker in early diagnosis of ATD and MCI patients and follow-up of their progression [1]. We would like to thank Uzun S. for the valuable com- ments and contributions for our paper [2]. Tese comments were useful for us. Choroidal thickness (CT) values may vary during the day and on diferent days [3]. As we specifed in our study, we performed optical coherence tomography (OCT) measurements on all participants on minimum 3 diferent days and 3 times consecutively in each measurement in order to ensure the lowest variation in CT values. We used the average of the measurements in our study. All measurements were performed from 9 a.m. to 11 a.m. Te systemic physiological and pathological conditions of people may also infuence CT values [3]. Recent studies showed that smoking and cofee decreased CT [4, 5]. Also some systemic diseases like cardiovascular disease, diabetes mellitus, and systemic arterial hypertension may afect CT [6]. Furthermore, sildenafl and pseudoephedrine-like drugs cause an increase in choroidal circulation and thickness [7]. As we mentioned in our study, to ensure minimum impact on CT data, participants with diabetes mellitus, cardiovascular disease, systemic arterial hypertension, and other serious chronic systemic diseases were excluded from our study. Furthermore, smokers were also excluded. All participants were instructed not to consume cafeine in 12 hours before the measurements. Moreover, patients who were taking sildenafl and pseudoephedrine-like systemic drugs, which might afect CT values, were not included in the study. OCT measurements of all participants were performed in a very cozy room where the light levels were adjusted. Using all the above-mentioned criteria, we tried to make sure that there was minimum impact on CT values. Finally, since we could not defnitively detect how long some of the ATD and MCI patients had had the disease at the time of the frst diagnosis, the correlation between the duration of the disease and CT was not analyzed in either ATD patients or MCI patients. Competing Interests None of the authors has fnancial and proprietary interests in any material or method mentioned and there is no public or private support. References [1] M. Bulut, A. Yaman, M. K. Erol et al., “Choroidal thickness in patients with mild cognitive impairment and Alzheimer’s type dementia,” Journal of Ophthalmology, vol. 2016, Article ID 7291257, 7 pages, 2016. Hindawi Publishing Corporation Journal of Ophthalmology Volume 2016, Article ID 5496356, 2 pages http://dx.doi.org/10.1155/2016/5496356