~ 152 ~ International Journal of Clinical Obstetrics and Gynaecology 2021; 5(5): 152-156 ISSN (P): 2522-6614 ISSN (E): 2522-6622 © Gynaecology Journal www.gynaecologyjournal.com 2021; 5(5): 152-156 Received: 16-07-2021 Accepted: 18-08-2021 Dr. Rekha Yadav Post Graduate 3rd Year, M.S Department of Obstetrics and Gynaecology, Teerthanker Mahaveer Medical College, Moradabad, Uttar Pradesh, India Dr. Kanchan Rani Professor, Department of Obstetrics and Gynaecology, Teerthanker Mahaveer Medical College, Moradabad, Uttar Pradesh, India Dr. Rehana Najam Professor and Head of Department, Department of Obstetrics and Gynaecology, Teerthanker Mahaveer Medical College, Moradabad, Uttar Pradesh, India Corresponding Author: Dr. Rekha Yadav Post Graduate 3rd Year, M.S Department of Obstetrics and Gynaecology, Teerthanker Mahaveer Medical College, Moradabad, Uttar Pradesh, India Maternal and fetal outcomes in pregnancies complicated with intrahepatic cholestasis of pregnancy Dr. Rekha Yadav, Dr. Kanchan Rani and Dr. Rehana Najam DOI: https://doi.org/10.33545/gynae.2021.v5.i5c.1033 Abstract Background: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease seen in pregnancy. By definition, ICP is apprehended to pregnancy and the post delivery period and is characterised following debarring of all other causes of cholestasis. Intrahepatic cholestasis of pregnancy affects 0·1–2% of pregnant women. Materials and Method: It is a retrospective study done at Teerthanker Mahaveer medical and research center, department of obstetrics and gynaecology including 128 females with intrahepatic cholestasis of pregnancy over a period of 2 years. Results: The mean age of the study population was 26.09±4.90 years and mean Gestational Age of the study population was 37.15±3.09 weeks. The clinical symptom of Jaundice was reported among 24.22% and Generalised Pruritus in second and third trimester was seen in all the patients. ALP was elevated in 44.44%, SGOT in 79.26%, SGPT in 73.33%, Total Serum bilirubin in 76.30%, Hypoglycemia in 11.11% and HbSAg was positive in 2.22% women. The perinatal outcome showed that Meconium was found in 37.04%, Apgar score at 1 minute (< 7) in 12.59%, Apgar score at 5 minutes (< 7) in 8.89%, Hyperbilirubinemia in 2.96% and NICU admission in 42.96% infants. Maternal complications and co- morbidities Pre-eclampsia is seen in 21.88%, hypoglycemia 10.16%, Hbsag in 3.13%, deranged coagulation profile 7.03% and post partum haemorrhage 14.06%. Interpretation: ICP is a comparatively frequent cause of hepatic deterioration in pregnancy. There are adverse pregnancy outcomes associated with intrahepatic cholestasis of pregnancy. Keywords: fetal outcomes, pregnancies complicated, intrahepatic cholestasis, pregnancy Introduction Intrahepatic cholestasis of pregnancy (ICP) is the most frequent liver disorder seen in pregnancy. It is ordinarily a reversible cholestatic disease seen commonly in the later half of pregnancy and is identified by pruritus predominantly of the palms and soles, increased levels of serum aminotransferases and/or increased serum bile acid levels (>or = 10micromol/L) with spontaneous alleviation of laboratory derangements and symptoms immediately after parturition but not after one month post- parturition [1, 2] . As per definition, ICP is apprehended to pregnancy and the post delivery period and is characterised following debarring all other causes of cholestasis. Usually incorporating with maternal symptoms, ICP can be associated with adverse neonatal outcomes, seen as meconium stained liquor amnii, premature labour and stillborn; hence, prompt identification and management are important [3] . It has been seen that 0·1–2% of pregnant females are affected by Intra hepatic cholestasis of pregnancy; [4, 6] . It is diagnosed in females with generalised pruritus in second and third trimester and with elevated serum bile acids, and complications can be seen as meconium stained liquor amnii, premature labour, and stillborn [7] . As per a large Swedish cohort study stated that pregnant females in which the serum bile acid concentration was of 40 μmol/L or more. These pregnancies were more predilected to be complicated by premature labour, meconium-stained liquor amnii, and birth asphyxia [8] . Another study on UK cohort stated that pregnancy outcome in females with intrahepatic cholestasis of pregnancy having serum bile acids of 40 μmol/L or more backed these findings and also displayed relation with intrauterine fetal demise (adjusted odds ratio = 3.05] when correlated with statistics from 2205 women with singleton pregnancies with no complications in the UK [3] .