Bulletin of Integrative Psychiatry  New Series  December 2019  Year XXV No. 4 (83)/89 BP I Bulletin of Integrative Psychiatry Buletin de Psihiatrie Integrativa Pemphigus vulgaris triggered by psychological stress Teona Asavei, Elena Porumb-Andrese, Dan Vâță, Mihaela Paula Toader, Adriana Ionela Pătrașcu, Alina Ioana Halip, Ioana Adriana Popescu, Laura Gheucă Solovăstru Teona Asavei - M. D., Dermatology Clinic County Emergency Hospital “St. Spiridon” Iași Elena porumb-Andrese - M.D. PhD, Assistant Professor, Department of Dermatology “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania Dan Vâță - M.D. PhD, Lecturer, Department of Dermatology “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania Mihaela Paula Toader - M.D. PhD, Lecturer, Department of Dermatology “Grigore T. Popa” University of Dental Medicine Iasi, Romania Adriana Ionela Pătrașcu - M. D., Dermatology Clinic County Emergency Hospital “St. Spiridon” Iași Alina Ioana Halip - M.D. PhD Student, Assistant Professor, Department of Dermatology “Grigore T. Popa” University of Medicine and Pharmacy Iași, Romania Ioana Adriana Popescu - M.D. PhD Student, Department of Dermatology “Grigore T. Popa” University of Medicine and Pharmacy Iași, Romania Laura Gheucă Solovăstru - M.D. PhD, Associated Professor, Department of Dermatology “Grigore T. Popa” University of Medicine and Pharmacy Iași, Romania ABSTRACT Pemphigus vulgaris (PV) is a rare but severe autoimmune disease caused by autoantibodies directed against desmosomes, and clinically characterized by bullae and painful erosions of the skin and mucous membranes. While the morphology is well defined, its etiopathogenesis remains a subject of research. PV, the most frequent and representative form of the autoimmune bullous dermatoses, has a poor prognosis in the absence of medical treatment. The onset and course of PV depend on a variable interaction between predisposing and inducing factors. Thus, drugs, viral infections (herpes simplex virus), physical agents, contact allergens, vaccinations, dietary factors, and psychological stress have been implicated in the disease. Stressful life events have been associated with the course of several autoimmune skin diseases and reported a possible factor in triggering and aggravating for pemphigus in predisposed patients. Psychological care,