Case Report
Ureteropelvic Junction Obstruction and Parathyroid Adenoma:
Coincidence or Link?
Salah Termos,
1
Majd AlKabbani,
1
Tim Ulinski,
2
Sami Sanjad,
3
Henri Kotobi,
2
Francois Chalard,
2
and Bilal Aoun
2,3
1
Hepatobiliary and Transplant Unit, Department of Surgery, Al-Amiri Hospital, Kuwait City, Kuwait
2
Pediatric Nephrology, Armand Trousseau Hospital, APHP, Paris, France
3
Division of Pediatric Nephrology, Department of Pediatrics, American University of Beirut, Beirut, Lebanon
Correspondence should be addressed to Salah Termos; salahtermos@gmail.com
Received 6 July 2017; Revised 11 September 2017; Accepted 25 September 2017; Published 17 October 2017
Academic Editor: Salih Kavukcu
Copyright © 2017 Salah Termos et al. Tis is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Congenital ureteropelvic junction obstruction (UPJO) is the most common cause of upper urinary tract obstruction in children.
It is generally diagnosed in the routine work-up during antenatal period and is characterized by spontaneous recovery. It can be
associated with urolithiasis; hence further investigation should be carried out. We report the case of a 15-year-old boy, who is known
to have right UPJO, presented with right renal colic and discovered to have bilateral kidney stones. Further studies showed primary
hyperparathyroidism and genetic analysis revealed a CDC73 mutation (initially HRPT2). We believe that association of UPJO
and PHPT is a rare coincidence that can be linked. Careful work-up of children with UPJO and urolithiasis is recommended to
exclude an underlying metabolic disease. Surgical correction can be evitable as treatment of the primary cause can lead to complete
dissolution of kidney stones and improvement of the medical condition.
1. Introduction
Ureteropelvic junction obstruction (UPJO) has a reported
incidence of 1 in 500 live births [1], more commonly in males
than females and more frequently found on the lef side.
It can be congenital or acquired, but congenital cases are
more common. It is considered the most common cause of
antenatally detected hydronephrosis [2, 3].
Management of UPJO depends on symptoms and split
renal function and it includes conservative management with
observation and follow-up or surgical intervention. UPJO
can lead to urolithiasis due to obstruction and urinary
stasis; however, metabolic causes of urolithiasis should be
investigated and ruled out [4–6]. We describe an unusual case
of UPJO associated with PHTP and kidney stones.
2. Case Presentation
In our manuscript, we report the case of a 15-year-old
boy with a longstanding history of unilateral ureteropelvic
junction obstruction who was presented for right fank pain
of three-month duration. Te patient had been followed up
for his right UPJO since birth, as he was diagnosed prenatally
to have hydronephrosis. An early ultrasound imaging of the
kidney was done at the age of three months and revealed
a right renal pelvis dilatation of 15 mm (anteroposterior
diameter) with normal kidney parenchyma. Later at the age
of three years, a follow-up ultrasound noted an increased
dilatation of the right pelvis up to 20 mm. Further studies
were carried out; a MAG-3 scintigraphy was performed and
showed a good contrast evacuation (10% residual radioac-
tivity, 20 minutes afer furosemide injection) and symmetric
kidney function (45% for the right kidney and 55% for the
lef). Furthermore, the child was followed regularly with renal
ultrasound that revealed a stationary course of pelvic dilation
within 15–20 mm without any clinical manifestation.
At the age of 15 years, the patient presented to our
institution for right fank pain, without urinary symptoms.
Renal ultrasound showed bilateral kidney stones (8 to
9 mm). A CT-scan of the abdomen showed a moderately
dilated right pelvis of 19 mm containing three stones, in
addition to two stones in a nondilated lef renal pelvis
Hindawi
Case Reports in Nephrology
Volume 2017, Article ID 9852912, 4 pages
https://doi.org/10.1155/2017/9852912