Impact of Acts of Discrimination on Quality of Life Among Injecting Drug Users in Delhi, India Enisha Sarin • Luke J. Samson • Michael D. Sweat Accepted: 28 May 2012 / Published online: 10 June 2012 Ó Springer Science+Business Media B.V. 2012 Abstract The study examines the association between quality of life (QOL) and discrimination perpetrated against a vulnerable population like injecting drug users (IDU). Given that QOL affects self efficacy which in turn affects behavior, it is relevant to examine QOL among IDUs in the context of HIV prevention, and to study whether discriminations and human rights abuses impact QOL in this population. A cross sectional study was conducted in two research sites in Delhi, India among 343 IDUs recruited through a respondent driven sampling. A Hindi version of the WHOQOL Bref survey along with a survey questionnaire of discrimination were used to interview participants. After controlling for demographic characteristics, experiencing physical and verbal abuse (OR: 0.46, CI 0.27–0.79),arrests and imprisonment for carrying needles and/or using drugs (OR: 0.53, CI 0.31–0.90) and lacking health information (OR: 0.49, CI 0.29–0.85)was associated with lower social QOL, while being denied health care services was associated with lower psychological QOL. The more discrimination experienced, the lower was the quality of life in the social and psychological domains. Participants’ perceived well being in the four domains was related to their living conditions, discriminatory acts and to perceptions of social support. Discriminatory acts and abuses appeared to have a greater toll on their psychological well being and social relationships, thus indicating the need for human rights advocacy in order to influence law enforcement practices and to reduce stigma, while expanding social support through an extended comprehensive IDU programme. E. Sarin (&) Independent Consultant, B7, 1st floor, Suncity, Sector-54, Gurgaon, Haryana 122002, India e-mail: esarin@jhsph.edu L. J. Samson Sharan, Society for Service to Urban Poverty, F-6/8A, Vasant Vihar, New Delhi 110057, India e-mail: lukessmail@aol.net M. D. Sweat Department of Psychiatry and Behavioral Sciences, Family Service Research Center, The Medical University of South Carolina, McClennan Banks 4th Floor, 326 Calhoun St. STE MC406, Charleston, SC 29401, USA e-mail: sweatm@musc.edu 123 Soc Indic Res (2013) 113:319–334 DOI 10.1007/s11205-012-0095-8