1 Tumor-educated uncommitted hematopoietic stem cells promote a metastatic switch Ksenia Magidey-Klein 1 , Ksenya Kveler 2 , Tim J. Cooper 1,2 , Rachelly Normand 2 , Tongwu Zhang 3 , Michael Timaner 1 , Ziv Raviv 1 , Brian James 4 , Roi Gazit 5 , Ze’ev A. Ronai 4 , Shai S. Shen-Orr 2,6 , Yuval Shaked 1,* . Affiliation 1. Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion Integrated Cancer Center, Technion, Haifa, Israel 2. Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel 3. Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, Bethesda, MD 4. Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 5. National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer- Sheva, Israel 6. Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel Running title: Tumor-educated HSCs promote metastasis *Correspondence Yuval Shaked Technion Integrated Cancer Center Faculty of Medicine Technion Haifa, Israel Office: 972-4-829-5215 Lab: 972-4-829-5238 Email: yshaked@technion.ac.il (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint this version posted August 25, 2020. ; https://doi.org/10.1101/2020.08.25.266189 doi: bioRxiv preprint